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GlossaryChromosome 17

contains genes crucial for cell growth and DNA repair

Chromosome 17 is one of the 23 pairs of chromosomes in humans and contains approximately 83 million base pairs, which represent about 2.5% of the total DNA in cells. It is notable for housing several important genes, including those related to the production of proteins involved in cell growth, DNA repair, and the development of the nervous system. Mutations or alterations in genes on Chromosome 17 can lead to various medical conditions, such as certain types of cancer and neurological disorders.

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research Congenital Generalized Hypertrichosis Terminalis with Gingival Hyperplasia and a Coarse Face: A Case Report

2 citations, March 2016 in “Serbian Journal of Dermatology and Venerology”

A six-year-old boy with excessive hair growth and other symptoms may have a genetic link on chromosome 17q, requiring regular medical follow-ups.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations, June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

research Size Polymorphisms in the Human Ultrahigh Sulfur Hair Keratin-Associated Protein 4, KAP4, Gene Family

27 citations, June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study found that variations in hair protein genes are likely due to evolutionary deletions or duplications.

research Human KAP Genes: Only Half of It? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes

53 citations, June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

KAP genes show significant genetic variability, but its impact on hair traits is unclear.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

62 citations, January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research The Human Type II Keratin Gene Cluster on Chromosome 12q13.13: Final Count or Hidden Secrets?

9 citations, February 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that the human keratin gene cluster is complex, with a need for updated naming to reflect over 50 functional genes important for hair and skin biology.

The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

70 citations, December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

research Polymorphisms in the Human High Sulfur Hair Keratin-Associated Protein 1, KAP1, Gene Family

48 citations, November 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

Genetic variations in hair keratin proteins exist but don't significantly affect hair structure.

research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino Acid Composition and Repeat Structure

51 citations, January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.

research Comparative Genomics of the Keratin-Associated Protein Gene Clusters in Human, Chimpanzee, and Baboon

8 citations, March 2004 in “Mammalian genome”

KAP genes are crucial for hair development and show both shared and unique traits in humans, chimpanzees, and baboons.

research Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes

74 citations, October 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

The 190-kbp domain contains all human type I hair keratin genes, showing their organization and evolution.

research Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling

16 citations, August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

MED1 is essential for normal hair growth and maintaining hair follicle stem cells.

research Development of Woolly Hair and Hairlessness in a CRISPR-Engineered Mutant Mouse Model with KRT71 Mutations

July 2023 in “Cells”

Researchers made a mouse model with curly hair and hair loss by editing a gene.

research Human Hair Keratin-Associated Proteins

71 citations, August 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Hair keratin-associated proteins are essential for strong hair, with over 80 genes showing specific patterns and variations among people.

research Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair, and Other Cornified Epithelial Structures

February 2025 in “Animals”

Understanding proteins in skin structures like claws and hair is crucial for future research.

research Disorders of the Hair and Nails

1 citations, January 2013 in “Elsevier eBooks”

The document reviews various hair and nail disorders, their causes, and treatments, emphasizing the need for proper diagnosis and the link between nail changes and systemic diseases.

research Understanding the Biochemical Properties of Human Hair Keratins: Self-Assembly Potential and Cell Response

January 2020

Human hair keratins can self-assemble and support cell growth, useful for biomedical applications.

research Evaluating the Antioxidant Effects of Human Hair Protein Extracts

12 citations, December 2017 in “Journal of biomaterials science. Polymer ed.”

Human hair protein extracts can protect skin cells from oxidative stress.

research Proteomic Characterization of Damaged Single Hairs Recovered After an Explosion for Protein-Based Human Identification

10 citations, May 2020 in “Journal of proteome research”

Explosions don't stop hair proteins from being used to identify people.

research Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression

14 citations, April 2016 in “PloS one”

The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.

research Differential Gene Expression Profiles in Fetal Skin of Rex Rabbits with Different Wool Density

4 citations, September 2016 in “World Rabbit Science”

High wool density in Rex rabbits is linked to specific gene activity affecting hair follicle development.

research The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes

10 citations, November 2021 in “International journal of molecular sciences”

Sheep and goat hair fibers are complex due to keratin-associated proteins, which are important for fiber properties and growth.

Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link Between the Embryonic Subperiderm and Feather Barbs and Barbules

research Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link Between the Embryonic Subperiderm and Feather Barbs and Barbules

22 citations, December 2016 in “PloS one”

A specific protein in chicken embryos links early skin layers to feather development.

research Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?

30 citations, August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

TGase 3 helps build hair structure by forming strong bonds between proteins.

research Diversity of Trichocyte Keratins and Keratin-Associated Proteins

16 citations, January 2018 in “Advances in experimental medicine and biology”

Hair and wool have diverse keratins and keratin-associated proteins.

research Lipid Levels in Women with Androgenetic Alopecia

15 citations, November 2010 in “International Journal of Dermatology”

Women with AGA have higher lipid levels, increasing heart disease risk.

research Hair for Brain Trade-Off: A Metabolic Bypass for Encephalization

3 citations, September 2014 in “SpringerPlus”

Human hair loss may have evolved to help increase brain size.

research Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments

65 citations, September 2014 in “BMC genomics”

Different hair types in mammals are linked to variations in specific protein genes, with changes influenced by their living environments.

research Expression Analysis of KAP9.2 and Hoxc13 Genes During Different Cashmere Growth Stages by qRT-PCR Method

9 citations, June 2014 in “Molecular biology reports”

KAP9.2 and Hoxc13 genes are important for cashmere growth and vary in activity during different stages.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

2 citations, August 2020 in “Scientific reports”

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.