Evaluating the Antioxidant Effects of Human Hair Protein Extracts

January 2018 in “ Journal of biomaterials science. Polymer ed. ”

Hui Ying Lai, Shuai Wang, Vaishali Singh, Luong Nguyen, Kee Woei Ng

human hair protein extracts antioxidant effects human dermal fibroblasts cysteine oxidative stress reactive oxygen species H2O2 HDFs ROS hydrogen peroxide

TLDR Human hair protein extracts can protect skin cells from oxidative stress.

The study evaluated the antioxidant effects of human hair protein extracts, highlighting their potential to protect human dermal fibroblasts (HDFs) from oxidative stress. The extracts, rich in cysteine (11.2 mol %), were characterized using various biochemical techniques and demonstrated significant antioxidant activity (IC50 = 16.22 μM). When added to cell culture media, the extracts maintained cell viability and reduced reactive oxygen species production in HDFs exposed to H2O2. These findings suggested that human hair protein extracts could be used in biomedical applications for their antioxidizing properties.

View this study on dr.ntu.edu.sg →

Discuss this study in the Community →

Cited in this study

9 / 9 results

research Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces

23 citations , January 2015 in “Stem cells international”

Coating surfaces with human hair keratin improves the growth and consistency of important stem cells for medical use.

research Structure–Property Relationships of Meta-Kerateine Biomaterials Derived from Human Hair

47 citations , January 2012 in “Acta biomaterialia”

Protein composition greatly affects the function of keratin biomaterials.

research Mechanical and Biological Properties of Keratose Biomaterials

140 citations , November 2011 in “Biomaterials”

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

research A Review of Keratin-Based Biomaterials for Biomedical Applications

517 citations , February 2010 in “Materials”

Keratin from hair and wool is used in medical materials for healing and drug delivery.

research The Use of Keratin Biomaterials Derived from Human Hair for the Promotion of Rapid Regeneration of Peripheral Nerves

309 citations , January 2008 in “Biomaterials”

Keratin from human hair helps nerves heal faster.

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-Associated Protein Genes on Chromosome 21q22.1

100 citations , December 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

research The Catalog of Human Hair Keratins

235 citations , July 1999 in “Journal of biological chemistry/The Journal of biological chemistry”

Human hair is made up of different keratins, some strong and some weak, with specific types appearing at various stages of hair growth.