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This review discusses recent advancements and ongoing challenges in engineering human skin with appendages using scaffold-free and scaffold-based bioengineering approaches, but it reports no new clinical results.

This study found that a collagen patch made with fibroblast-derived extracellular matrix (fdECM) extracted from human lung fibroblasts enhanced wound healing by promoting wound contraction, angiogenesis, and skin remodeling in full-thickness skin wound models, including those with diabetic ulcers.

This research found that a biodegradable fibrous membrane incorporating fibroblast-derived ECM accelerated wound healing and improved neovascularization in a mouse model.

This study found that a silk fibroin/sodium alginate scaffold effectively delivers human umbilical mesenchymal stem cells to promote scarless wound healing and hair follicle regeneration in vivo by inducing specific cellular processes and mitigating endoplasmic reticulum stress.

This research reported that a newly developed dually crosslinked gelatin-alginate-based hydrogel scaffold enhances mechanical strength, promotes corneal tissue regeneration, and reduces scarring in rabbit models, suggesting potential applications in corneal tissue engineering.

This study found that silk fibroin gel induced more pro-regenerative macrophages and hair follicle stem cells, leading to almost scarless skin regeneration compared to alginate gel.

This chapter reviews traditional and tissue-engineered treatments for skin defects and discusses advances in bioengineered skin constructs, but it presents no new experimental results.

This review discusses advances in skin tissue engineering, focusing on scaffold-free approaches and the application of stem cells, and reports no new research findings.

This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.

This study developed thermo-reversible glycol chitosan hydrogels that effectively form and maintain 3D cell spheroids within one day, offering a simplified method for creating biologically realistic cultures for tissue regeneration and drug screening applications.

This study developed a protocol for acellular dermal matrix manufacturing from pig skin, demonstrating effective removal of cellular components while preserving the collagen scaffold's structural organization through a series of physical and chemical treatments.

This review explores the potential of nanofiber scaffolds as an advanced intervention in peripheral nerve regeneration, detailing their fabrication, cellular interactions, controlled bioactive agent release, clinical translation prospects, emerging trends, and biocompatibility considerations for treating peripheral nerve injuries.

This study demonstrated that using a perfusion culture bioreactor and 3D spheroid culture can enhance corneal endothelial cell expansion and support the construction of tissue-engineered corneal endothelial layers in vitro.

This study demonstrated that decellularization of rat lungs effectively removed cellular material while preserving the 3D extracellular matrix, which may aid future human lung tissue engineering.

In this study, researchers suggest that strategic early intervention during fetal wound healing could lead to significantly improved long-term skin regeneration outcomes.

This study found that electrospun membranes with aligned surface topography enhanced wound healing and hair follicle regeneration while modulating the immune response in a mouse skin wound model.

In a study using mouse models, researchers developed a gelatin methacryloyl scaffold with calcium-doped silica nanoparticles loaded with deferoxamine, which significantly improved skin flap survival and hair follicle growth, suggesting potential clinical applications in tissue regeneration.

This study found that combining mesenchymal stromal cells from adipose tissue and hair follicles with soy protein and β-chitin scaffolds significantly reduced wound healing time and improved skin regeneration in vivo.

This study found that hydrogels supplemented with fractionated platelet-rich plasma recruited more dermal-derived stem cells and accelerated healing, leading to hair growth and skin regeneration in rats.

This review discusses recent advances in developmental tissue engineering for regenerating ectodermal appendages like teeth and glands, emphasizing biomaterial selection and cell culture strategies, but reports no new experimental results.

This study reports that tissue-engineered skin using ES cell-derived epidermal stem cells and collagen sponge successfully healed full thickness skin defects in mice, forming epidermis and structures resembling glands and hair follicles.

This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.

In this study, the researchers reported that using a biodegradable ECM scaffold for large-area wound regeneration accelerated wound coverage and improved hair follicle neogenesis by activating the adaptive immune system.

In this review, it is discussed how mesenchymal stem cell aggregation plays a crucial role in organ development and has potential applications in organ regeneration through tissue engineering.

This study found that incorporating PCL-based nanoscaffolds into liver spheroids enhances their viability and liver-specific biofunctionality, suggesting these scaffolds improve the model's potential for preclinical drug screening by increasing sensitivity to acetaminophen toxicity compared to traditional methods.

In this study, collagen scaffolds functionalized with heparin and growth factors significantly enhanced long-term skin regeneration and growth in a sheep model of fetal skin defect, suggesting potential for prenatal spina bifida treatment.

This study introduces a new multiaxial bioreactor system that uniformly stretches tissue-engineered skin grafts and improves skin tissue maturation through enhanced cellular distribution and environmental monitoring.

This study examined 3D-printed scaffolds coated with polydopamine and observed that they significantly enhanced osteogenesis and angiogenesis in vitro and in a rat cranium defect model, suggesting their potential for repairing large bone defects.

This study demonstrated that transplanting in vitro differentiated Wharton's jelly mesenchymal stem cells on acellular dermal grafts led to complete skin regeneration with appendages in a mouse model of full-thickness wounds.