Rapid Angiogenic Hydrogel Nanofiber Scaffold Promotes Random Flap Regeneration and Modulates Inflammation

March 2025 in “ Wound Repair and Regeneration ”

Jhih-Hao Liang, Yang Zou, Haiyan Ju, Yonggang Lv

gelatin methacryloyl hydrogel nanofiber scaffold calcium-doped silica nanoparticles deferoxamine hair follicle growth inflammation modulation tissue engineering

TLDR The hydrogel scaffold improved skin flap healing and reduced inflammation.

The study developed a gelatin methacryloyl (GM) hydrogel nanofiber scaffold containing calcium-doped silica nanoparticles loaded with deferoxamine (GM/CD-1) to enhance random skin flap regeneration. The GM/CD-1 scaffold demonstrated excellent biocompatibility and significantly improved flap survival in mice, achieving a 96.17 ± 3.17% survival rate at 14 days. It also stimulated hair follicle growth and modulated inflammation, indicating its potential for clinical applications in flap regeneration and tissue engineering.

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