Rapid Angiogenic Hydrogel Nanofiber Scaffold Promotes Random Flap Regeneration and Modulates Inflammation

The study investigates the use of a gelatin methacryloyl (GM) hydrogel nanofiber scaffold containing calcium-doped silica nanoparticles loaded with deferoxamine (GM/CD-1) to enhance the regeneration of random skin flaps, which are often used to cover thick skin wounds. The GM/CD-1 scaffold demonstrated excellent biocompatibility and significantly improved flap survival in mice, achieving a 96.17% survival rate at 14 days. Additionally, it promoted hair follicle growth and modulated inflammation, indicating its potential for clinical applications in flap regeneration and tissue engineering.