15 citations
,
September 2002 in “Journal of Biological Chemistry” This study observed that transgenic mice expressing keratin K10 under bovine K6beta control developed severe oral abnormalities, suggesting keratin composition changes can affect the physiology of epithelial cells, especially in the oral mucosa.
13 citations
,
February 2024 in “Cureus” This review discusses the emerging role of platelet-rich plasma in bone healing and reports no new clinical results; it highlights promising outcomes from existing research and calls for further standardization and exploration in this field.
13 citations
,
November 2023 in “International Journal of Nanomedicine” This review explores the potential of nanofiber scaffolds as an advanced intervention in peripheral nerve regeneration, detailing their fabrication, cellular interactions, controlled bioactive agent release, clinical translation prospects, emerging trends, and biocompatibility considerations for treating peripheral nerve injuries.
11 citations
,
January 2025 in “Regenerative Therapy” This review highlights the potential of bioengineered dermal scaffolds in tissue engineering to enhance wound healing by mimicking the dermal structure and supporting cellular processes, while also discussing recent advancements and challenges in scaffold technology.
4 citations
,
July 2024 in “BMC Zoology” This study found that the structure and mineral content of dromedary camel hair, specifically the medulla patterns, medulla index, and elemental composition, change with age, revealing differences among camels aged 1 year, 3-5 years, and 8-10 years.
3 citations
,
January 2024 in “Cell Transplantation” This study reviews various factors affecting mesenchymal stem cell transplantation efficacy, including platelet concentrate composition, donor characteristics, and environmental influences, and examines strategies for optimizing outcomes through preconditioning and combined therapies in regenerative medicine.
2 citations
,
May 2023 in “Marine Drugs” The researchers reported that marine-derived saccharides, specifically L-fucose and chondroitin sulphate disaccharide, supported skin and hair health by promoting cellular proliferation, enhancing extracellular matrix production, and aiding the hair cycle's growth phase, potentially minimizing aging effects.
1 citations
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June 2025 in “Fermentation” This study found that solid-state fermentation using probiotic lactic acid bacteria significantly enhanced the antioxidant properties and bioactive composition of Radix Angelica gigas compared to non-fermented herbs, suggesting a potential method for modernizing traditional herbal medicine.
July 2025 in “Annals of Human Genetics” This review examines the genetics of acne vulgaris, concluding that stem/progenitor cell maintenance and cellular migration are key processes in its pathogenesis, potentially shifting future treatment strategies beyond traditional antibiotics and retinoids, which have notable side effects.
December 2024 in “Microorganisms” This study analyzed changes in the microbiota during antler velvet regeneration in sika deer and found significant differences in microbial community composition between 15 and 30 days post-pedicle casting, highlighting the potential roles of specific bacteria in wound healing and tissue regeneration.
June 2023 in “SPIRE - Sciences Po Institutional REpository” This study suggests that extracellular vesicles from prostate cancer cells could aid in identifying tumor heterogeneity and serve as biomarkers, while also playing a role in SARS-CoV-2 infection in nasopharyngeal mucus.
May 2022 in “Голова и шея.” This study found a direct correlation between chronic tonsillitis and increased NETosis activity in peripheral blood and palatine tonsil lacunae.
305 citations
,
June 2012 in “Nature” This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.
156 citations
,
October 2012 in “Seminars in Cell & Developmental Biology” This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.
24 citations
,
March 2022 in “Genome biology” This study introduces scINSIGHT, a method that showed improved performance over existing approaches in identifying gene expression patterns and cellular processes in heterogeneous scRNA-seq datasets from different biological conditions.
18 citations
,
April 2021 in “PLOS ONE” This systematic review found that most level I/II clinical studies on platelet-rich plasma therapy have focused on musculoskeletal injuries, but inconsistent reporting of PRP composition complicates comparisons across medical specialties.
3 citations
,
January 2025 in “JID Innovations” This review reports that the unique tunnel structures in advanced hidradenitis suppurativa impair quality of life and resist biological therapy, with their formation involving complex cellular and molecular interactions, including microbial dysbiosis, all contributing to ongoing inflammation and scarring.
3 citations
,
October 2024 in “Frontiers in Medicine” This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.
March 2026 in “Frontiers in Pharmacology” The study concluded that the Exprecell™ device for preparing anticoagulant-free f-PRF increases volume yield and simplifies the process while maintaining biological activity comparable to conventional methods, suggesting potential clinical utility.
January 2026 in “Burns & Trauma” This review synthesizes evidence on how RNA modifications affect wound healing, particularly in skin, bone, and corneal injuries, emphasizing potential therapeutic strategies for burns and trauma in relation to these cellular processes.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.
12 citations
,
September 2024 in “JID Innovations” This review highlights the potential of microfluidic skin-on-a-chip models in skin research, emphasizing their ability to mimic human skin structure and improve control over cellular and molecular distribution compared to traditional in vitro models.
610 citations
,
April 2014 in “Nature Reviews Immunology” This review discusses the complex mechanisms regulating skin immunity to balance host defense with inflammation, but reports no new findings.
318 citations
,
January 2022 in “Signal Transduction and Targeted Therapy” This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.
295 citations
,
September 2006 in “Cell Cycle” This review discusses the role of the TOR pathway in aging and suggests that rapamycin could potentially target age-related diseases, but reports no new clinical results.
252 citations
,
February 2018 in “npj Regenerative Medicine” This review explores recent advances in understanding molecular mechanisms of tissue regeneration in mammals and suggests potential therapeutic targets, but it reports no new clinical results.
211 citations
,
April 2018 in “Cold Spring Harbor Perspectives in Biology” Keratins are crucial for cell structure, growth, and disease risk.
140 citations
,
August 2011 in “Biomaterials” This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.
105 citations
,
January 2010 in “Mediators of Inflammation” This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.
102 citations
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July 2007 in “Genes & Development” This study found that maternal PPARγ is essential for preventing the production of inflammatory lipids in mouse milk, which can otherwise cause inflammation, alopecia, and growth retardation in nursing pups.