Hidradenitis Suppurativa Tunnels: Unveiling a Unique Disease Entity

Hidradenitis suppurativa (HS) tunnels are advanced structures in the disease that significantly impair quality of life and resist current medical therapies, often requiring surgical intervention. These tunnels are characterized by epithelial-lined structures within the dermis and contribute to a cycle of inflammation and disease progression, involving activated keratinocytes, microbial dysbiosis, and IL-17–producing T cells. The study highlights the need for further research into the mechanisms of tunnel formation and persistence to develop targeted therapies, as current treatments, including biological medications, show limited efficacy. The document emphasizes the importance of understanding the cellular and microbial interactions in HS tunnels to improve patient outcomes and reduce the healthcare burden.