Update on Hidradenitis Suppurativa: Connecting the Tracts
December 2014
in “
F1000 prime reports
”
hidradenitis suppurativa abscesses sinus tract formation scarring basement membrane folliculopilosebaceous unit bacterial colonization biofilms antibiotic resistance triple-antibiotic therapy TNF-α inhibitors IL-1 inhibitors laser therapy surgical excision comorbidities psychosocial issues HS TNF-alpha inhibitors
TLDR The document concludes that Hidradenitis suppurativa is often underdiagnosed, lacks definitive treatment, and requires better awareness and management strategies.
The document provided an update on hidradenitis suppurativa (HS), a chronic skin disease characterized by recurrent abscesses, sinus tract formation, and scarring. It highlighted the disease's underdiagnosis and the need for improved awareness and classification systems. Advances suggested a defective basement membrane at the sebofollicular junction as a potential initiating factor, with secondary bacterial colonization complicating treatment. Treatments included antibiotics, biologics targeting TNF-α and IL-1, laser therapy, and surgical options, though many patients continued to experience significant physical and psychosocial distress. The document also discussed the association of HS with obesity, smoking, inflammatory bowel disease, spondyloarthritis, and metabolic syndrome, emphasizing the need for further research and standardized scoring systems to enhance management and treatment outcomes.
