September 2022 in “Research Square (Research Square)” This study found that overexpressing Rps14 in supporting cells promoted hair cell regeneration in the organ of Corti by facilitating cell proliferation and differentiation.
26 citations
,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.
16 citations
,
July 2020 in “Advanced functional materials” This review discusses the development and application of cell-derived matrices in regenerative medicine and disease modeling, presenting various fabrication techniques and future perspectives, but reports no new results.
6 citations
,
July 2023 in “Nature cell biology” In this study, re-activating SOX9 in adult epidermal stem cells led to a fate switch towards hair follicle stem cell identity, with altered chromatin dynamics and oncogenic activation, contributing insights into developmental processes and cancer pathways.
January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, the researchers found that deleting ceramide synthase 4 in the skin's epidermis alters stem cell differentiation, disrupting hair follicle structure and barrier function, potentially leading to immune responses similar to atopic dermatitis.
January 2016 in “Elsevier eBooks” This review discusses three aspects of cell fate specification across Metazoa and reports no new experimental results, highlighting the formation of nematode equivalence groups, evolution of echinoderm skeletogenic mesoderm, and adult cell fate regulation.
5 citations
,
February 2015 in “Journal of Comparative Pathology” This study suggests that high proliferative activity and peripheral invasion are key indicators of malignancy in canine sebaceous gland tumours. It also reports a higher incidence of circumanal gland and testicular tumours, indicating a possible androgen-related pathway in tumour development.
January 2026 in “Immune Network” This review discusses the heterogeneity of Tregs in normal and tumor environments, emphasizing the complexity of targeting tumor-resident Tregs while maintaining systemic immune tolerance, but reports no new findings.
4 citations
,
July 2025 in “Frontiers in Immunology” This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.
351 citations
,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
321 citations
,
March 2015 in “Nature” This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.
301 citations
,
February 2019 in “Nature Communications” In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.
205 citations
,
August 2007 in “Experimental Cell Research” This review discusses advances in understanding mammalian stem cell niches, particularly in bone marrow, tooth, and hair follicle, and highlights the potential for developing therapies targeting these niches for tissue repair.
137 citations
,
April 2015 in “Nature Reviews Molecular Cell Biology” This review discusses the distinct roles and surprising developmental flexibility of multiple somatic stem cell types in tissue maintenance and repair, reporting no new results but highlighting emerging questions about their regulation and origins.
136 citations
,
May 2019 in “Cells” This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.
133 citations
,
February 2019 in “PLoS Biology” This research found that feather pattern formation in birds is regulated by a mechanochemical system involving fibroblast growth factor and bone morphogenetic protein signaling, which is altered in the flightless emu and ostrich.
124 citations
,
February 2018 in “Nature Reviews Genetics” This review covers recent findings on stem cell plasticity under normal and cancerous conditions but presents no new experimental results, highlighting implications for regenerative medicine and cancer treatments.
113 citations
,
November 2017 in “Scientific Reports” This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.
112 citations
,
May 2020 in “Nature Communications” This study found that cardiac fibroblasts significantly enhance the maturation of neonatal mouse and human embryonic stem cell-derived cardiomyocytes, suggesting a pivotal role in postnatal heart development and disease.
96 citations
,
June 2017 in “Nature Communications” This study identified WNT10A as crucial for adult epithelial cell proliferation and differentiation, suggesting β-catenin pathway activation may help address regenerative defects in WNT10A mutation patients.
76 citations
,
June 2018 in “EMBO Reports” This study demonstrates that YAP and TAZ are essential for initiating basal and squamous cell carcinomas in mice, and suggests targeting these pathways could be beneficial for treating skin cancers.
74 citations
,
January 2013 in “Expert Opinion on Biological Therapy” This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.
66 citations
,
July 2015 in “Journal of Molecular Biology” This review discusses how macro-environmental factors such as intradermal adipose tissue and sex hormones influence hair and feather stem cell niches, suggesting environmental targets for regenerative medicine, but reports no new clinical results.
54 citations
,
January 2009 in “British Journal of Dermatology” This study found that in scarring alopecia, stem cells are differentially localized, suggesting that both inner and outer root sheath stem cells, rather than just follicular bulge stem cells, are involved.
53 citations
,
August 2019 in “American journal of human genetics” This study found that FOXN1 haploinsufficiency is a significant genetic factor causing T cell lymphopenia at birth, linked to reduced thymic function in both humans and mice.
50 citations
,
December 2013 in “Stem Cells” This review discusses the enhanced understanding of how stem cell niches respond adaptively to systemic signals, aging, and local perturbations, but reports no new research findings.
49 citations
,
September 2007 in “Journal of Investigative Dermatology” The study found that bioengineered hair follicles work when using cells from the same species but have issues when combining human and mouse cells.
47 citations
,
January 2017 in “RSC Advances” Keratin peptides can change hair shape gently without harsh chemicals.
43 citations
,
April 2021 in “Angiogenesis” This review examines the evolving understanding of lymphatic vessel development, emphasizing new cellular mechanisms and lineage diversity, while discussing experimental methods and identifying key knowledge gaps.
42 citations
,
February 2017 in “Scientific Reports” In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.