Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

mIGF-1 in skin cells speeds up wound healing and hair growth in mice without harmful effects.

This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice.

Seborrheic dermatitis affects quality of life and sleep, linked to stress and nervous system changes.

This study identified key genes and miRNAs involved in feather morphogenesis in Zhedong White geese, highlighting a negative correlation between FOXO3 and miR-144-y.

This study found that ocu-miR-205 influences hair follicle density and signaling pathways in Rex rabbits by promoting dermal papilla cell apoptosis and altering hair follicle phases.

This study identified a novel phase of stem cell quiescence, GAlert, in mice, regulated by mTORC1, that primes stem cells for injury response.

In this study, researchers identified 47 proteins associated with male pattern baldness severity and prioritized five candidate genes, including druggable CD38, suggesting new non-hormonal targets for therapeutic development.

This review examines the role of Hairless, a nuclear receptor corepressor, in regulating Wnt signaling during hair cycling and reports no new clinical results.

This study found that vanillic acid from wheat bran promoted dermal papilla cell proliferation, potentially stimulating hair growth by activating the PI3K/Akt and Wnt/β-catenin pathways.

This study found that using a novel dissolving microneedle with valproic acid effectively enhances hair follicle regrowth through improved delivery and activation of the Wnt/β-catenin pathway compared to topical application.

This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results.

This review discusses the potential of exosome-based therapies in dermatology, highlighting their ability to treat conditions like alopecia and accelerate wound healing, though further research is needed to understand long-term safety and develop standardized clinical protocols.

This review outlines the functional anatomy, pathology, and molecular mechanisms of androgenetic alopecia, emphasizing the need for multi-omics approaches to better understand this condition's biology.

The K15 promoter effectively targets stem cells in the hair follicle bulge.

In this study, different types of catagen in the C57BL/6 mouse model exhibited varying effects on hair follicle melanocytes and melanin distribution, with spontaneous and dexamethasone-induced catagen showing pigment incontinence, while cyclophosphamide-induced catagen retained dendritic melanocytes but increased ectopic melanin.

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

This study found that the retinol dehydrogenases SDR16C5 and SDR16C6 in mice play a crucial role in skin retinol dehydrogenase activity, affecting hair growth and gland functions without impacting survival.

This review summarizes research on scar formation and inhibition mechanisms, discussing emerging therapies like gene therapy and stem cell treatments, but notes ongoing challenges for clinical application, including treatment personalization and outcome sustainability.

This study demonstrated that an aloe polysaccharide-collagen wound dressing improved wound healing by enhancing angiogenesis and reducing inflammation in vivo.

This study found that PTEN regulates the number and genomic stability of hair follicle stem cells in the skin, with its deficiency leading to increased stem cell accumulation and senescence through interactions with BMAL1 and BMI-1.

This review highlights the importance of apoptosis in the hair cycle, particularly its role in hair follicle regression and loss, suggesting that understanding its mechanisms can aid in developing treatments to reduce hair loss and promote hair growth.

This review discusses recent evidence on the Notch signaling pathway's role in regulating hair follicle development and stem cell differentiation, but provides no new research findings.

This mathematical model of alopecia areata illustrates how inflammatory autoimmune responses interrupt the anagen phase of hair growth, and may help evaluate treatments and identify new therapeutic targets.

This review discusses recent advancements in understanding how the sympathetic nervous system and norepinephrine regulate hair follicle growth, highlighting innovative studies that explore their effects on hair follicle stem cells.

This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.

This chapter discusses stem cell activity in feather and hair follicles, emphasizing how stem cells maintain their population by cycling between quiescence and activation in specialized niches but reports no new results.

This study found that modulating BMP activity in transgenic mice affects the development and characteristics of several ectodermal organs, such as skin, hair, and claws, highlighting a stage-dependent influence on organogenesis.

This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.

This review article reports recent advancements in understanding, diagnosing, and treating various hair loss conditions, like androgenetic alopecia and alopecia areata, including their genetic factors and new therapeutic options, while also examining the impact of COVID-19 on hair loss.

This study found that the loss of transcription factor Ovol2 in epidermal and hair follicle stem cells leads to migration defects, which are partially improved by deleting the EMT-inducing Zeb1.