In this study, applying a 5% concentration of pomegranate peel extract significantly enhanced hair growth on male rabbits, showing results comparable to the positive control using 2% Minoxidil, but higher concentrations or lower concentrations did not perform as well.
March 2025 in “Jurnal Farmamedika (Pharmamedica Journal)” In this study, Indonesian spices were screened in silico for their potential to inhibit MMP9 and TNFα, which are involved in chronic diabetic wounds, and procyanidin was identified as the most promising therapeutic candidate due to its low binding energy to both proteins.
June 2017 in “Asian journal of pharmaceutical and clinical research” This study found that a green tea extract gel was stable across various temperatures, did not cause eye irritation, and significantly increased eyelash growth compared to a placebo after two months of use in human volunteers.
February 2025 in “Journal of Fundamental and Applied Pharmaceutical Science” In this experimental study, the researchers developed and evaluated a hair tonic made from mangosteen peel extract, finding that all four tested formulations showed suitable physical characteristics and met standard requirements for attributes like pH, viscosity, and stability.
16 citations
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April 2017 in “Journal of Cosmetic Dermatology” This study found that fig leaf extract significantly downregulated inflammatory and androgenic gene expression in vitro, suggesting potential topical benefits for certain skin disorders.
January 2024 in “Jurnal Ilmiah Ibnu Sina (JIIS) Ilmu Farmasi dan Kesehatan” In this study, researchers developed a hair tonic using shallots (Allium cepa L.) and found that its F2 formulation was as effective as the positive control in promoting hair growth on the 21st day and remained stable over 28 weeks of testing.
This study found that a cream containing 20% broad bean extract may reduce axillary hair growth, but only some outcomes were statistically significant compared to placebo.
48 citations
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May 2021 in “Molecules” The researchers found that plant extracts from Papaver rhoeas L., Clitoria ternatea L., and Carthamus tinctorius L. are effective natural cosmetic dyes, offering intense and stable colors without cytotoxicity.
3 citations
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May 2021 in “Genetics and Biodiversity Journal” In this study, the ethanolic extract of Citrullus colocynthis demonstrated strong antioxidant activity and reduced cancer cell numbers in vitro, suggesting potential for pharmacological use.
4 citations
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March 2021 in “Asian Journal of Beauty and Cosmetology” This study found that Dendropanax, sea salt, spinach, and kelp were safe and potentially effective as ingredients in functional cosmetics aimed at alleviating hair loss symptoms.
January 2021 in “AIP conference proceedings” This research found that the most cost-effective extraction for developing a coffee-based hair serum is from fall grade cherry coffee, which balances active ingredient content and material cost effectively.
9 citations
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May 2015 in “Media Penelitian dan Pengembangan Kesehatan” This study found that a gel containing apigenin and celery juice improved hair growth in male Spraque-Dawley mice without causing significant skin irritation.
This study explored chitosan-based dissolving microneedle arrays loaded with Agave tequilana root extract, finding that extract concentration influenced microneedle geometry and bioactivity, maintaining antioxidant and enzyme inhibitory effects while reducing collagenase inhibition, particularly in the 0.25% formulation.
This study found that ethanolic plant extract of Peperomia pellucida increased hair length in rabbits in a dose-dependent manner but did not significantly affect hair mass compared to controls.
July 2026 in “Functional Foods in Health and Disease” In this study, oral administration of strawberry guava extract promoted hair growth in both mice and humans, with active components like adenosine, fructose, digalactosyldiacylglycerol, and pedunculagin contributing by enhancing skin blood flow and activating dermal papilla cells.
2 citations
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November 2019 in “Phytotherapy Research” This study found that consuming 100 mg of pea sprout extract daily for 8 weeks significantly reduced hair loss in individuals experiencing excessive hair shedding.
1 citations
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October 2017 This study found that topical gel containing ethanolic extract of Peperomia pellucida increased hair length in rabbits, but did not significantly impact hair mass compared to control treatments.
In this study, aqueous and aqueous-alcoholic extracts of Ajuga reptans showed promising hepatoprotective and wound-healing properties, with significant effects observed in experimental models, suggesting potential for development into official medicinal products pending further research.
14 citations
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April 2019 in “Saudi pharmaceutical journal” This study reported that microparticle-loaded emulsions containing caffeic acid achieved more homogeneous distribution and prolonged release in hair follicles, suggesting potential for effective folliculitis treatment.
January 2009 in “The Chinese Journal of Dermatovenereology” The study found that Tribulus terrestris extract, when administered in varying doses to C57BL/6J mice, may significantly increase MC-1R expression in hair follicle melanocytes.
December 2025 in “JURNAL PIJAR MIPA” This study found that a natural hair tonic spray formulated from 15% water pumpkin fruit extract promoted rabbit hair growth to a degree comparable to a synthetic control.
23 citations
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November 2015 in “Phytotherapy Research” This study found that cucurbitacin I from bitter melon most effectively inhibited the growth of lung cancer cells and promoted hair cell growth in cell cultures.
June 2021 in “SWU eJournals System (Srinakharinwirot University)” The study found that cyproterone acetate could be released over 15 days using coconut oil mixed with certain wax inhibitors, though further safety studies are needed.
2 citations
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August 2016 in “Journal of Investigative Dermatology” 10 citations
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November 2022 in “International Journal of Cosmetic Science” In this laboratory study, Camellia japonica fruit shell extract showed potential to mitigate hair loss by promoting hair cell growth and reducing harmful effects of DHT and oxidative stress.
26 citations
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January 2016 in “Annals of Dermatology” This study found that Ecklonia cava polyphenols increased human dermal papilla cell proliferation and extended hair shaft length in vitro and ex vivo, suggesting potential as a therapeutic candidate for hair loss.
January 2026 in “Lumbung Farmasi Jurnal Ilmu Kefarmasian” This study found that a topical emulsion containing purified extracts of sidr leaves and roasted candlenut seeds significantly increased hair growth compared to the base and 2% minoxidil, potentially through their antioxidant and anti-inflammatory properties.
9 citations
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January 2014 in “DARU Journal of Pharmaceutical Sciences” This study found that Cuscuta reflexa extracts promoted hair regrowth and follicular proliferation in cyclophosphamide-induced hair loss in male rats.
33 citations
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December 2023 in “Cell Death Discovery” This study found that cepharanthine can inhibit gastric cancer cell activity by inducing oxidative stress and altering energy metabolism, suggesting its potential for gastric cancer treatment.
19 citations
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August 2010 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses plant extracts for dermatological use, highlighting evidence that some can reduce edema in chronic venous insufficiency or help treat actinic keratoses, but it reports no new clinical results.