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RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.

HPV8 causes hair follicle stem cells to grow, leading to skin lesions.

Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.

HPV8 E6 gene causes growth of certain skin stem cells.

Inactive hair follicle stem cells help prevent skin cancer.

Patched1 helps prevent tumors by controlling cell growth.

The Kras mutation changes normal cell signals, leading to disrupted tissue structure and potential cancer.

A specific mutation in Kras causes abnormal tissue changes by making a cell signal continuously active, which disrupts normal cell coordination.

Key genes linked to hair growth and cancer were identified in hairless mice.

KRT80 may worsen cancer by increasing growth and spread, but its full effects on treatment and outcomes need more research.

Shh and Dhh affect skin development and can cause tumors, while Ihh does not.

Understanding where cancer cells come from helps create better prevention and treatment methods.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

Oncogenic K-ras causes rapid cancerous changes in the mouth's lining.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

RNA aptamers can specifically block FGF5-related cell growth, potentially treating related diseases or hair disorders.

The treatment was ineffective in humans.

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

Distinct β-catenin patterns are linked to cell growth, not cell death, in lung cancer.

BAY 43-9006 helps control kidney cancer growth but doesn't significantly increase overall survival.

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

High lactate dehydrogenase activity is not necessary for the growth of squamous cell carcinoma.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

A small group of slow-growing cells causes basal cell carcinoma to return after treatment.

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.