Specific Inhibition of FGF5-Induced Cell Proliferation by RNA Aptamers
February 2021
in “
Scientific Reports
”
Researchers developed RNA aptamers that specifically inhibited FGF5-induced cell proliferation without affecting FGF2-induced proliferation. One aptamer, F5f1, showed high affinity to FGF5 (Kd = 0.7 ± 0.2 nM) and not to other FGFs or FGFR1. A truncated version, F5f1_56, exhibited even higher affinity (Kd = 0.118 ± 0.003 nM). These aptamers could potentially be used therapeutically for FGF5-related diseases or hair disorders due to their high specificity and inhibitory effects on FGF5.
