58 citations
,
April 2009 in “Current stem cell research & therapy” This review discusses the differentiation and reprogramming capabilities of both hematopoietic and non-hematopoietic stem cells and their significance for regenerative medicine; it reports no new experimental results.
56 citations
,
February 2013 in “International Journal of Molecular Medicine” This study found that human hair follicle-derived mesenchymal stem cells maintained their proliferation and differentiation potential when cultured with acidic fibroblast growth factor, basic fibroblast growth factor, or epidermal growth factor.
52 citations
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June 2009 in “Clinical Toxicology” This article reviews the clinical features, diagnosis, and treatment of acute radiation syndrome caused by ingesting (210)polonium, emphasizing the need for supportive care and potential benefits of chelation therapy.
37 citations
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July 2016 in “Current Opinion in Cell Biology” This review summarizes recent discoveries about how tissue-resident stem cells interact with their environments during normal conditions and after injury, without reporting new results.
19 citations
,
October 1971 in “The BMJ” Anticonvulsant drugs may cause temporary chromosomal abnormalities.
16 citations
,
July 2025 in “Journal of Translational Medicine” In this study, MSC-scaffold combinations were found to significantly enhance wound closure, collagen deposition, angiogenesis, and growth factor expression while modulating inflammatory responses in preclinical burn wound models, though significant heterogeneity limits immediate clinical application.
16 citations
,
February 2013 in “Molecular Medicine Reports” This study found that CD34+ cells from adipose tissue may enhance hair morphogenesis and participate in blood vessel formation in reconstituted skin tissues of mice.
14 citations
,
February 2008 in “Stem Cells and Development” This study identified several genes highly expressed in germ-line stem cells that are also common in hematopoietic stem cells, potentially aiding the exploration of fundamental stem cell commonalities.
13 citations
,
November 2024 in “Frontiers in Microbiology” This review assessed the potential of mesenchymal stem cell therapy to enhance burn wound healing, highlighting its capabilities in promoting angiogenesis, reducing inflammation, and regenerating damaged tissues, while identifying preclinical and clinical challenges that need addressing to optimize treatment outcomes.
13 citations
,
November 2023 in “International Journal of Nanomedicine” This review explores the potential of nanofiber scaffolds as an advanced intervention in peripheral nerve regeneration, detailing their fabrication, cellular interactions, controlled bioactive agent release, clinical translation prospects, emerging trends, and biocompatibility considerations for treating peripheral nerve injuries.
13 citations
,
February 2023 in “Biology” This review highlights the potential of cell-free therapies, particularly cell extracts, in addressing radiation-induced salivary gland damage from head and neck cancer treatment, emphasizing their practicality and safety compared to traditional therapies despite incomplete understanding of their bioactive components.
13 citations
,
June 2014 in “Molecular therapy” This study found that a lentiviral array of reporters can identify lineage-specific promoters and pathways in mesenchymal stem cell differentiation, aiding in the prediction of signaling pathway effects.
11 citations
,
March 2014 in “Journal of Investigative Dermatology” In this study, basal cell carcinoma developed in Ptch-deficient mice only after chemical treatment, not skin wounding, suggesting a second unknown event is necessary for tumor formation.
8 citations
,
July 1996 in “Annals of Internal Medicine” This report documented a case of thrombocytopenia and leukopenia linked to the long-term use of itraconazole in a patient with acute myelogenous leukemia.
8 citations
,
January 1977 in “Acta Haematologica” This study found that the PVP protocol, combining Peptichemio, vincristine, and 6-methylprednisolone, resulted in remission for diffuse non-Hodgkin's lymphomas with moderate side effects.
5 citations
,
January 2023 in “IDCases” In this case report, a 45-year-old man developed acute fatal pancytopenia and other severe adverse reactions 10 days after starting albendazole and praziquantel for pulmonary cystic echinococcosis.
5 citations
,
October 2001 in “British Journal of Ophthalmology” This abstract describes the initial success of intralesional cidofovir for SCC treatment and states that it has not shown systemic toxicity, but it does not report new clinical trial results.
3 citations
,
April 2020 in “PubMed” This study found that DEB-BACE combined with systemic chemotherapy was more effective than chemotherapy alone for unresectable lung squamous cell carcinoma, reducing side effects and improving survival rates.
2 citations
,
November 2025 in “PLoS ONE” This study found that CDK4/6 inhibitors for HR+/HER2- advanced breast cancer are linked to typical adverse events such as fatigue and neutropenia, while also identifying unexpected reactions, highlighting potential safety concerns in their real-world use.
2 citations
,
June 2024 in “Frontiers in Immunology” In this study, researchers developed a 3D in-vitro system for generating functional AT-resident macrophages without cell sorting, providing a valuable tool to study their differentiation and function in various physiological and pathological conditions.
2 citations
,
July 2023 in “International Journal of Clinical and Experimental Medicine Research” This study found that for thyroid cancer patients who underwent radical mastectomy, the combination of CAF regimen and fufangbanmao capsule improved short-term clinical efficacy, enhanced immune function, reduced drug toxicity, and positively impacted quality of life compared to the CAF regimen alone.
2 citations
,
November 2013 This article discusses dermatologic adverse events associated with topoisomerase inhibitors and anthracyclines, such as alopecia and hand-foot syndrome, but reports no new clinical results.
2 citations
,
December 2010 in “Zhonghua neifenmi daixie zazhi” This study found that autologous nonmyeloablative hematopoietic stem cell transplantation may help some newly-onset type 1 diabetes patients become insulin-free, although gastrointestinal and other mild side effects were observed.
1 citations
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January 2026 in “GigaScience” This study introduces Cell Journey, a new platform for visualizing RNA velocity in 3D, which aims to better capture complex cellular transitions in single-cell datasets compared to current 2D methods.
1 citations
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January 2020 in “Recent Research in Genetics and Genomics/Recent Research in Genetics and Genomics ” In this study, high doses of Lepidium sativum seeds extract were reported to cause toxicity and tissue damage in animals, suggesting the need for careful use under medical supervision.
1 citations
,
May 2017 in “The Journal of Internal Korean Medicine” This case study reports that a patient receiving Bojungikki-tang alongside chemotherapy showed improvement in hair loss despite ongoing treatment, suggesting a potential benefit for chemotherapy-induced alopecia.
1 citations
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January 2017 in “Japanese Journal of Oral & Maxillofacial Surgery” In this case study, a woman with secondary syphilis showed significant improvement following treatment with benzyl penicillin potassium, as evidenced by a 3.7-fold decrease in rapid plasma reagin levels.
October 2025 in “Preprints.org” This research concludes that adipose mesenchymal stem cells are uniquely evolved to manage skin inflammation in newborns and their released molecules are the safest and most effective for skin therapeutics.
This systematic review reported that treatment with drugs that activate the Wnt pathway, including valproic acid and lithium, was not associated with a significant increase in cancer risk. The authors suggest further research on Wnt activation's potential as a regenerative therapy.
January 2025 in “Case Reports in Hematology” In this case report, a 17-year-old female with symptoms such as vaginal bleeding and weight loss was diagnosed with B-cell acute lymphoblastic leukemia, emphasizing the importance of considering hematological malignancies in young patients with unusual presentations, as early diagnosis can significantly improve outcomes.