Unusual Presentation of Childhood Leukemia With Vaginal Bleeding: A Case Report

January 2025 in “ Case Reports in Hematology ”

Şule Çalışkan Kamış

hair loss Philadelphia chromosome B-cell acute lymphoblastic leukemia BCR-ABL dasatinib chemotherapy cytopenias

TLDR Leukemia should be considered in teens with unexplained bleeding.

This case report discusses a 17-year-old female who presented with unusual vaginal bleeding, weight loss, and hair loss, leading to the diagnosis of Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph+ B-ALL). Laboratory tests revealed leukocytosis, anemia, and thrombocytopenia, and bone marrow analysis confirmed B-ALL with the BCR-ABL p190 transcript. The patient was treated with the BFM-ALL 2009 chemotherapy protocol and dasatinib. This case underscores the importance of considering leukemia in adolescents with unexplained bleeding and cytopenias, contributing to the limited literature on atypical presentations of Ph+ B-ALL.

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