Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that while MSC concentration in BMCs correlates with total cell counts, cellularity does not indicate high MSC content.

This study found that high-dose Cyclosporin A in rats led to significant functional and structural changes, including liver, kidney, and immune system alterations, along with behavioral and hematological effects.

This article discusses the interest in folic acid antagonists for leukemia treatment, noting their potential mechanism of interfering with cellular growth, but reports no new clinical results.

This study found that hair follicle mesenchymal stem cells are similar to bone marrow stem cells in most characteristics, but differ in their adipogenic and osteogenic differentiation capabilities, suggesting they may be a suitable source for adipogenesis research.

This study found that, in male patients with patellar tendinopathy, bone marrow mesenchymal stromal cell treatment improved tendon regeneration, organization, strength, and pain relief more effectively than leukocyte-poor platelet-rich plasma over 12 months.

This study demonstrated that autologous mesenchymal stem cells from hair follicles, when combined with a novel gelatin-based hydrogel, showed promising osteogenic potential and could offer a non-invasive alternative for bone regeneration.

This study found that deleting Snai2 and Snai3 genes in mice disrupts immune cell development, resulting in severe autoimmunity and early death due to the loss of immune tolerance.

This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.

This study found that combining adipose-derived mesenchymal stromal cells with meglumine antimoniate reduced lesion size and parasite load in mice with leishmaniasis, suggesting potential for improved treatment.

In this study, aleglitazar and its metabolite M6 were evaluated for safety in non-clinical settings, revealing organ-targeting effects common to PPAR agonists but no significant tumor increase in rat carcinogenicity studies, supporting progression to Phase 3 clinical trials.

This review explores how platelet- and marrow-derived biologics like PRP and BMAC exhibit both regenerative and antimicrobial properties useful in musculoskeletal conditions and wound healing, though their clinical outcomes are affected by preparation inconsistencies and lack of standardized protocols.

This review discusses the role of stem cells in cutaneous wound healing and reports no clinical results; the authors highlight the need for better understanding of underlying mechanisms for future therapies.

This study reports that systemic lupus erythematosus with aplastic anemia is rare in children but highlighted serious outcomes, including a high infection rate and significant mortality, underscoring the need for vigilant management.

Treatments for acute leukaemia lead to high remission rates, but relapses occur, requiring ongoing advancements in care.

This review discusses the potential roles of calcium in the regulation of pluripotent and tissue-specific stem cells but reports no new experimental results, highlighting areas for future research.

Wharton's Jelly stem cell medium may help treat skin issues in Systemic Sclerosis.

This study presented cases where potentially significant germline variants were unexpectedly found during genomic profiling for myeloid malignancies, discussing the challenges in genetic counseling and management, especially when variants don't match the patient's condition.

This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.

This review discusses the development of electrospun nanofibrous scaffolds for promoting angiogenesis in tissue engineering but notes that their clinical application beyond bone and skin repair is still limited.

This study reports that two mouse models of scarring alopecia exhibit similar patterns of hair loss progression despite histological differences in inflammatory cell localization and MHC class I expression.

This study found that stimulating toll-like receptor 5 via mucosal delivery of a flagellin-containing fusion protein effectively extended lifespan and enhanced healthspan in mice, including improved bone density and cognitive capacity.

This article highlights the versatility and potential of alginate and its derivatives in tissue engineering applications, discussing their properties, modification techniques, and various uses in enhancing tissue healing, bone regeneration, and cell growth.

This review examines experimental studies on the synergistic use of platelet-rich plasma and adipose-derived mesenchymal stem cells for wound healing in animal models, without reporting new clinical outcomes.

This review summarizes the current understanding of Wnt signaling in relation to its roles in tissue regeneration and cancer progression and discusses recent medical advancements targeting this pathway for therapeutic purposes.

This study found that using cultured mesenchymal stem cells from mouse whisker hair follicle outer root sheath in wound healing reduced inflammation, accelerated closure, and resulted in less hypertrophic scarring in mice.

In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.

This study found that radiofrequency treatment, with or without hydrolyzed collagen, increased dermis thickness, neocollagenesis, and FGF2 overexpression in rat skin tissue.

This article provides industry updates on stem cell research and regenerative medicine from December 2019 and reports no new research findings.

This narrative review discusses the role of injectable biomaterials in dental tissue regeneration, highlighting their suitability for treating small, hard-to-access oral defects compared to pre-formed scaffolds, and explores the potential use of nanofibers in dental applications.

This report describes a case of a man developing hair changes, including Beau's lines and Pohl-Pinkus constrictions, following ABVD chemotherapy.