Cellularity as a Predictive Tool for Mesenchymal Stem Cell Concentration in Bone Marrow Concentrates: Implications for Regenerative Medicine

This study explores the use of cellularity as a predictive tool for mesenchymal stem cell (MSC) concentration in bone marrow concentrates (BMCs) for regenerative medicine, using 41 patient samples. It finds a strong correlation between total cell count and MSC numbers, suggesting cellularity can estimate MSC concentration, though not their percentage. The proximal femur is identified as an optimal site for harvesting due to higher MSC yields. Despite significant cell loss during centrifugation, this has minor clinical relevance. The findings aim to standardize BMC preparation protocols, enhancing therapeutic applications for conditions like osteoarthritis.