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In this study, the researchers reported that activin B combined with bone marrow-derived mesenchymal stem cells enhanced wound healing and hair follicle regeneration in rats by promoting cell migration through the ERK and JNK pathways.

In this study, researchers found that hydrogel scaffolds loaded with Runx2-overexpressing BMSCs significantly enhanced bone regeneration and osteogenic differentiation, offering new insights into treating large bone defects.

This study demonstrated that epidermal neural crest stem cells and bone marrow-derived stem cells migrated toward inflammatory brain lesions in rats and were successfully tracked using noninvasive MRI.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

This review explores the potential of using genetically-manipulated stem cells as both therapeutic agents and gene delivery vehicles for enhanced wound regeneration, but it reports no new clinical results.

This study found that combining Panax notoginseng saponins with bone mesenchymal stem cells significantly enhanced diabetic cutaneous ulcer healing in rats by reducing inflammation and promoting new epidermis formation through specific molecular pathways.

This study observed that bone marrow mesenchymal stem cells cultured in three-dimensionally bioprinted hydrogels with higher stiffness, like 3A8G, tend to differentiate more into hair follicle cells compared to those in less stiff hydrogels, like 1A4G.

This study found that GDNF promotes hair formation and skin wound repair by enhancing the self-renewal and differentiation of bulge stem cells in mice.

This study found that injecting bone marrow-derived mesenchymal stem cells and conditioned medium into mice promoted hair follicle stem cell proliferation and transition to active growth phases, suggesting potential clinical targets for hair loss treatment.

This study found that gelatin sponges used as scaffolds in rats with deep wounds and periosteal defects enabled regeneration of diverse tissue types, including periosteum, skin, and appendages, highlighting the role of vascular niche formation.

This study found that altering cyclin-dependent kinase 4 (CDK4) levels in the bulge region of hair follicles affects the balance of stem cell numbers, potentially influencing hair follicle self-renewal and proliferation.

This study found that knocking out vinculin in mouse skin disrupts bulge stem cell quiescence by impairing force generation and mechanical stability of adherens junctions.

This study reported that stem cells derived from semi-solid bone marrow improved the healing of diabetic incision wounds in rats by increasing epidermal thickness and blood vessel growth, and reducing hair follicle destruction, cellular penetration, diffuse fibrosis, and necrosis compared to control groups.

This study found that GDNF promotes hair formation and wound repair in mice by enhancing the function of bulge stem cells.

This study found that human embryonic and induced pluripotent stem cells differentiated into specific bulge stem cells and successfully formed new hair follicles when transplanted with mouse dermal cells in immunodeficient mice.

This study found that while MSC concentration in BMCs correlates with total cell counts, cellularity does not indicate high MSC content.

This study found that direct co-culture of human bone marrow-derived mesenchymal stromal cells with regulatory T cells enhanced osteogenic gene expression, alkaline phosphatase activity, and matrix mineralization, suggesting Treg's potential in promoting bone regeneration by modulating BMSC mechanobiology through the ROCK-myosin signaling pathway.

This study found that far-infrared radiation preconditioning significantly enhanced the proliferation, survival, and migration of bone marrow-derived stem cells in vitro, indicating potential therapeutic benefits for cardiac ischemia treatment.

In this rat study, bone marrow mesenchymal stem cell therapy reduced mortality and intestinal damage in acute liver failure by alleviating endotoxemia.

This study reports that bone marrow derived cells can become a source of epithelial cells in tumor development, contributing significantly to skin lesions like papillomas and ulcers in a skin carcinogenesis model.

This study suggests that Dicer, but not Tarbp2, plays a crucial role in regulating the growth phase of hair follicles in bulge stem cells during post-natal development in mice.

This study found that hydrogels loaded with exosomes from bone marrow mesenchymal stem cells helped bone fracture healing by reducing inflammation, promoting blood vessel formation, and supporting bone regeneration, as confirmed in a mouse model.

This study reported that high-intensity red LED irradiation increased osteogenic differentiation and mineralization of human bone marrow mesenchymal stem cells, potentially through Wnt/β-catenin pathway activation.

This study reports that Lef1 plays a crucial role in promoting bulge stem cell differentiation towards hair fate by activating β-catenin and downstream signaling pathways during hair follicle development.

This study found that strontium ranelate promotes cartilage regeneration in rats by enhancing chondrogenic differentiation of bone mesenchymal stem cells while inhibiting the Wnt/β-catenin signaling pathway.

In this study, shear-thinning silk nanofiber hydrogels were found to enhance retention of mesenchymal stem cells and accelerate wound healing in rat models.

This study found that primary stem cells from concentrated growth factor can differentiate into adipogenic, endothelial, and neuronal lineages in vitro, suggesting potential for use in regenerative therapies.

This study found that bone marrow mesenchymal stem cells from Guizhou miniature pigs showed stable growth and multidirectional differentiation potential, making them ideal for tissue engineering applications.