A Narrative Review of the Research Progress and Clinical Application of Platelet-Rich Plasma

March 2021 in “ Annals of palliative medicine ”

Yiqiu Cao, Xuelian Zhu, Ruixin Zhou, Yayi He, Zhourui Wu, Yu Chen

platelet-rich plasma PRP growth factors cell proliferation tissue regeneration

TLDR PRP shows promise in healing but needs a standardized, safe preparation method.

The review discussed the progress and clinical applications of platelet-rich plasma (PRP), highlighting its use in dermatology for hair loss, orthopedics for arthritis, and sports medicine for tendon injuries due to its rich content of growth factors. Despite its potential in promoting cell proliferation and tissue regeneration, PRP's clinical use was limited by infection risks, lack of standardized preparation protocols, and high costs. The review emphasized the need for safe, standardized PRP preparation methods to maximize its therapeutic potential and called for further research to address these issues.

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Research cited in this study

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research A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

348 citations, July 2017 in “Skin appendage disorders”

Platelet-rich plasma shows promise for skin and hair treatments but needs more research and standardization.

research Platelet-Rich Plasma for Androgenetic Alopecia: Does It Work? Evidence from Meta-Analysis

64 citations, March 2017 in “Journal of Cosmetic Dermatology”

PRP treatment may increase hair density and reduce hair loss, but more research is needed.

research Applications of Platelet-Rich Plasma in Dermatology: A Critical Appraisal of the Literature

79 citations, October 2015 in “Journal of Dermatological Treatment”

Platelet-rich plasma may have some benefits in dermatology, but there's not enough evidence to widely recommend its use.

research Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia

59 citations, May 2014 in “Expert Opinion on Therapeutic Targets”

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations, March 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth

166 citations, September 2011 in “Dermatologic Surgery”

Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.

Related Community Posts Join

6 / 77 results

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Nice & pure PRP, 3 ml of this is going to the scalp.

in Research/Science 32 upvotes 2 years ago

The use of PRP to treat hair loss and its potential effectiveness when combined with 5 alpha reductase blockers such as Minoxidil or Finasteride.

community Reddit’s amatorial meta analysis of 17 already avaliable hair loss prevention treatments that were found to be effective in clinical studies but are not FDA approved for MPB. PROS and CONS. (2022 Guide if Finasteride and Minoxidil are not working/ give you sides/are not enough) 77 studies linked!

in Research/Science 586 upvotes 2 years ago

The post and conversation are about hair loss treatments that have been found to be effective in studies. There are 19 different treatments mentioned, including oral minoxidil, oral dutasteride, topical finasteride, RU58841, and more. The best treatment for an individual depends on factors like availability, cost, side effects, and personal preferences.

community What else is good. Besides the big 3.

in Chat 36 upvotes 1 month ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community How can I get fin in Canada (GP and Derm turned me down) + questions on minoxidil and PRP

6 upvotes 6 years ago

Treatments for hair loss with a focus on finasteride, minoxidil, and platelet-rich plasma (PRP). The user discussed their family history of balding, asked questions about the effectiveness of different treatments, and was discouraged from taking finasteride by medical professionals.

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research Platelet-Rich Plasma as a Site-Targeted Approach in Wound Healing: A Molecular Perspective

7 citations, December 2018 in “Discoveries”

Platelet-rich plasma may improve wound healing by stimulating cell growth and blood vessel formation.

research Platelet-Rich Plasma—An 'Elixir' for Treatment of Alopecia: Personal Experience on 117 Patients with Review of Literature

31 citations, July 2017 in “Stem cell investigation”

Platelet-rich plasma (PRP) is a simple, cost-effective treatment that promotes hair growth and reduces hair loss, with high patient satisfaction.

Engineered Exosomes and Composite Biomaterials for Tissue Regeneration