This study observed that exosomes derived from adipose-derived stem cells significantly enhanced bone marrow mesenchymal stem cell migration and osteogenesis, leading to improved bone regeneration in a rat model of calvarial defects.
March 2021 in “Research Square (Research Square)” This study found that strontium ranelate may promote cartilage regeneration by enhancing chondrogenic differentiation and inhibiting the Wnt/β-catenin signaling pathway in rat models of cartilage defects.
606 citations
,
January 2016 in “International Journal of Cell Biology” This review outlines recent advances in stem cell and tissue engineering technologies in regenerative medicine and wildlife conservation, reporting no new clinical results.
10 citations
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January 2014 in “BioMed research international” In this study, dermal papilla cells from rat vibrissae showed potential for treating CNS injuries by secreting neurotrophic factors and promoting neuronal differentiation more effectively than bone marrow mesenchymal stem cells.
January 2016 in “Journal of Materials Chemistry B” Advancements in biomaterials and nanotechnology are improving medical applications like hair growth, bone regeneration, and cancer treatment.
13 citations
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August 2015 in “Oncology Reports” This study found that human adipose tissue-derived mesenchymal stem cells inhibited A549 tumor growth but significantly promoted HT-29 tumor growth in mouse models, highlighting opposing effects depending on the cancer type.
July 2019 in “Cancer Research” This study found that bone marrow-derived epithelial cells were abundantly recruited to some skin tumors in mice, indicating a systemic contribution to cutaneous neoplasms.
July 2019 in “Tumor Biology” In this study, researchers found that bone marrow-derived epithelial cells significantly contribute to the development of cutaneous tumors and dysplastic ulcers in mice, indicating a potential systemic role in skin cancer development.
January 1996 in “Journal of Dermatological Treatment” Dermatologists should know about cosmetic science and aesthetics because patients care about skin appearance and health.
5 citations
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May 2021 in “BMC surgery” This report of a rare case describes cutis verticis gyrate secondary to cerebriform intradermal nevus, emphasizing individualized treatment plans based on patient preference and condition severity.
November 2024 in “BMC Surgery” This article notes the increasing incidence of androgenetic alopecia in males and the growing acceptance of follicular unit extraction as a treatment, but reports no new clinical results.
26 citations
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October 2020 in “Pediatric Dermatology” This study found that oral tofacitinib led to clinically significant improvement in alopecia areata severity scores among pre-adolescents, though results varied and further evaluation in clinical trials is needed.
7 citations
,
August 2021 in “Journal of the European Academy of Dermatology and Venereology” This study suggests that early initiation of treatment in fibrosing alopecia in a pattern distribution may lead to a more favorable outcome, as evident in some patients experiencing arrested disease progression and hair regrowth.
39 citations
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February 2021 in “Journal of The American Academy of Dermatology” In this study, low-dose oral minoxidil for hair loss was associated with infrequent systemic adverse effects, and only 1.7% of patients discontinued treatment due to these effects.
5 citations
,
September 2020 in “Journal of The American Academy of Dermatology” This study reported that low-dose oral minoxidil combined with a 5α-reductase inhibitor improved hair density in most men with female pattern hair loss after 6 months or more of treatment.
47 citations
,
February 2021 in “Pharmacological research” This review discusses the potential of endogenic and exogenous exosomes in dermatology and cutaneous aesthetics, highlighting their capacity to repair and rejuvenate skin tissue, but reports no new experimental results.
40 citations
,
June 2013 in “Molecular Pharmaceutics” This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.
28 citations
,
December 2012 in “The American Journal of Cosmetic Surgery” This study reported that treatments using ADSC-CM improved hair growth in all participants, with the most pronounced results after four sessions within three to four months.
18 citations
,
December 2018 in “Expert Opinion on Biological Therapy” This review discusses hair follicle stem cells for wound healing and reports no new clinical results, noting their potential but emphasizing the need for further understanding and safety in clinical applications.
December 2024 in “Research Square (Research Square)” In this phase I/II clinical trial, placenta-derived mesenchymal stem cell exosome therapy significantly improved hair density and diameter, and reduced hair loss in patients with androgenetic alopecia, though further large-scale studies are needed to confirm these results and investigate the underlying molecular mechanisms.
411 citations
,
April 2010 in “Gastroenterology” This review explores various theories of colorectal cancer stem cell biology and highlights the need for better identification and targeting of these cells to advance treatment strategies, but reports no new clinical findings.
3 citations
,
May 2019 in “Cytotherapy” In this study, only a subset of proposed biomarkers universally responded to priming in mesenchymal stromal cells, suggesting limited utility for standardized potency assays across different MSC types and conditions.
June 2022 in “Research Square (Research Square)” This study suggests that hair follicle mesenchymal stem cells may alleviate small intestinal ischaemia-reperfusion injury in rats by promoting angiogenesis, reducing apoptosis, and protecting intestinal mucosal function.
November 2021 in “Research, Society and Development” This review covers different treatment options for alopecia areata and androgenetic alopecia and emphasizes individualized treatment plans, combining pharmacological therapy with psychological support; no new clinical results are reported.
262 citations
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May 2017 in “Nanomedicine” This review examines recent advancements in electrospun nanofibers for wound healing applications, but reports no new experimental results, highlighting their potential in sutures, dressings, and skin regeneration.
245 citations
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January 2018 in “Bone Research” This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.
232 citations
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October 2015 in “International journal of molecular sciences” This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.
220 citations
,
March 2020 in “Advanced functional materials” This review discusses the mechanisms and potential therapeutic benefits of mesenchymal stromal cell-derived extracellular vesicles delivered via biomaterials, but reports no new clinical results.
187 citations
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April 2019 in “npj Regenerative Medicine” This study found that hMSC secretomes from umbilical cord Wharton's jelly had the most potent angiogenic effects, whereas those from adipose tissue demonstrated the weakest angiogenic potential.
182 citations
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June 2017 in “Biomaterials” This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.