136 citations,
October 2019 in “Journal of Clinical Investigation” Dermal adipose tissue in mice can change and revert to help with skin health.
129 citations,
July 2019 in “Stem Cell Research & Therapy” Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
128 citations,
August 2020 in “Cell stem cell” Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.
105 citations,
October 2017 in “Stem cells” Wnt signaling is crucial for skin development and hair growth.
79 citations,
January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology” Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.
68 citations,
January 2015 in “Indian Journal of Dermatology” Microneedling can effectively promote new hair growth in men with hair loss who didn't improve with traditional treatments.
66 citations,
June 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.
64 citations,
January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Human stem cells can help form hair follicles in mice.
63 citations,
May 2009 in “Dermato-endocrinology” Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.
55 citations,
March 2010 in “Aging” Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.
54 citations,
January 2023 in “Signal Transduction and Targeted Therapy” New therapies are being developed that target integrin pathways to treat various diseases.
46 citations,
April 2014 in “PLOS ONE” Gray hair may be caused by lower antioxidant activity in hair cells.
44 citations,
July 2016 in “Stem Cells Translational Medicine” Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.
44 citations,
January 2015 in “Development” Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.
42 citations,
June 2019 in “Aging” 3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.
38 citations,
February 2021 in “Journal of Investigative Dermatology” Aging slows wound healing due to weaker cells and immune response.
38 citations,
December 2020 in “International journal of biochemistry & cell biology” Keratin proteins are essential for keeping the cells in the human colon healthy and stable.
37 citations,
June 2019 in “Stem cells” Special particles from skin cells can promote hair growth by activating a specific growth signal.
35 citations,
January 2017 in “Journal of Dermatological Science” Stress can cause early aging in certain skin cells, leading to problems with hair growth.
35 citations,
December 2009 in “Differentiation” Desmoglein 4 is controlled by specific proteins that affect hair growth.
35 citations,
September 2006 in “American Journal Of Pathology” Odontogenic keratocysts are caused by abnormal Hedgehog signaling and can lead to tooth and bone issues.
33 citations,
May 2018 in “Stem Cell Reports” Krt15+ cells in the mouse intestine resist radiation and can start tumors.
32 citations,
July 2017 in “Molecular diagnosis & therapy” MicroRNA-21 could help diagnose and treat skin fibrosis.
32 citations,
April 2017 in “Scientific Reports” Platelet-rich plasma can help grow more mouse hair follicles, but it doesn't work for human hair follicles yet.
31 citations,
July 2017 in “Stem cell investigation” Platelet-rich plasma (PRP) is a simple, cost-effective treatment that promotes hair growth and reduces hair loss, with high patient satisfaction.
29 citations,
January 2021 in “Journal of Investigative Dermatology” Fat under the skin releases HGF which helps hair grow and gain color.
26 citations,
August 2008 in “Clinical endocrinology” The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.
26 citations,
January 2007 in “Organogenesis” Bioengineering can potentially treat hair loss by regenerating hair follicles and cloning hair, but the process is complex and needs more research.
24 citations,
March 2020 in “Cells” Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.
21 citations,
June 2018 in “Journal of Investigative Dermatology” Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.