Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that modulating BMP activity in transgenic mice affects the development and characteristics of several ectodermal organs, such as skin, hair, and claws, highlighting a stage-dependent influence on organogenesis.

This study found that overexpressing the BMP inhibitor Noggin in transgenic mice led to a significant loss of nontylotrich hair follicles, suggesting a critical role for BMP signaling in hair follicle morphogenesis and cycling.

This study found that androgens downregulate BMP2 in dermal papilla cells, inhibiting hair follicle stem cell differentiation, while BMP2 addition may restore hair lineage differentiation through the Wnt/β-catenin pathway.

This study found that mTOR signaling plays a crucial role in activating hair follicle stem cells by balancing BMP-mediated repression, essential for hair regeneration.

This study found that the BMP antagonist noggin induces hair growth in postnatal skin by neutralizing BMP4's inhibitory activity, potentially mediated by changes in Shh expression.

In this study with organ-cultured human scalp hair follicles, high mTORC1 activity correlated with gray/white hair and reduced pigmentation, while inhibiting mTORC1 with rapamycin increased hair growth and pigmentation, suggesting mTORC1 inhibition could be a strategy for treating hair depigmentation and loss.

This review examines the roles of Smad-4 and Smad-7 in hair follicle differentiation and development through BMP signaling and TGFβ/Activin/BMP pathway inhibition but reports no new experimental results.

In this study, Min pigs were found to have unique characteristics for secondary hair growth compared to Berkshire and Yorkshire pigs, with the Wnt and BMP signaling pathways stimulating follicle stem cell activity and promoting secondary hair growth and gene expression.

This study found that Sp6 overproduction in ameloblast-lineage cells increased cell proliferation and ameloblastin expression, suggesting that Sp6 promotes amelogenesis by inhibiting follistatin gene expression.

This study observed that topical application of maslinic acid stimulated hair growth in mice comparably to minoxidil, possibly through the Wnt/β-catenin pathway and involving ciliary gene activity, highlighting increased levels of trichogenic gene expression and protein levels.

This study found that Cur-Fe-mesoporous silica nanoparticles synergistically inhibited scar formation and promoted hair follicle regeneration in skin burn wound healing by releasing bioactive components like SiO32−, Fe3+, and Fe-Cur chelates.

In a depilated mouse model, this study found that blocking CXCL4 activity with an anti-CXCL4 monoclonal antibody promoted hair growth by inducing an earlier anagen phase, delaying hair follicle regression, and altering expression of genes and proteins related to hair growth and cell proliferation.

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

This study found that TAZ promotes adipogenesis in goat adipose-derived mesenchymal stem cells by enhancing PI3K/AKT pathway activity, with overexpression boosting adipocyte formation and knockdown inhibiting it.

In this study, transgenic male mice over-expressing the androgen receptor in mesenchymal stem cells showed reduced fat mass and improved glucose clearance, suggesting enhanced androgen sensitivity may alter body composition.

This study found that a titrated extract of Centella asiatica enhanced the hair growth potential of 3D spheroid cultured human dermal papilla cells.

This study reviews the regulatory mechanisms and molecular processes governing stem cell activity in hair follicles, highlighting their roles in hair regeneration and potential implications for treating hair and skin disorders.

This study found that Avicennia marina extract significantly increased hair growth in androgenic alopecia patients, suggesting its potential effectiveness by inhibiting 5 alpha-reductase and regulating relevant growth factors.

This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.

This article explores the dynamic and energy-efficient nature of telogen hair follicles, challenging the notion of dormancy, and highlights their potential in advancing treatments for hair growth disorders.

This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.

In this study, the authors explored the role of Lgr5+ hair follicle stem cells and their regulation through the Wnt/-catenin pathway, highlighting how precise modulation of this pathway is crucial for treating hair loss safely and effectively.

In this study using lab models, YangHyulEum Gami-Bang (YHEG) was associated with promoting hair growth and inhibiting factors that contribute to hair loss.

This study found that hair follicles across mouse skin form a heterogeneous regenerative field, with distinct cycling dynamics influenced by the balance of activator and inhibitor signals, which could inform other organ regeneration research.

This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.

This study found that follistatin and activin interactions are important for hair follicle development and cycling in mice, suggesting that they may regulate processes involving BMP-2 and its antagonist.

This study concluded that Wnt/β-catenin signaling, through Shh and Bmp pathways, is crucial for determining hair follicle fate in embryonic epidermal development.

This study found that in a population of hair follicles, regenerative cycling stages are regulated by both intrinsic and extrinsic signals, with WNT/BMP signaling mediating interactions among follicles for adaptability.

This review discusses the role of the CXXC5 protein as a transcription factor and signaling coordinator, noting its involvement in embryonic development, tissue homeostasis, and diseases such as tumorigenesis, but reports no new experimental findings.

This study suggests that an in ovo injection of CHIR-99021 promoted feather growth and follicle development in goose embryos by activating the Wnt signaling pathway.