TAZ Enhances the Activity of the AKT Signaling Pathway to Promote Adipogenesis of gADSCs
September 2025
in “
Stem Cell Research & Therapy
”
Studysummary This study found that TAZ promotes adipogenesis in goat adipose-derived mesenchymal stem cells by enhancing PI3K/AKT pathway activity, with overexpression boosting adipocyte formation and knockdown inhibiting it.
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The study explores the role of TAZ in the adipogenesis of goat adipose-derived mesenchymal stem cells (gADSCs), finding that TAZ overexpression promotes adipogenesis by enhancing the PI3K/AKT signaling pathway. TAZ overexpression increases lipid accumulation and the expression of adipogenic markers like PPARγ, CEBPα, and FABP4, while its knockdown inhibits these processes. The study also highlights TAZ's influence on the nuclear-cytoplasmic translocation of itself and YAP, suggesting a mechanism for regulating adipogenesis. These findings offer insights into the molecular mechanisms of adipogenic differentiation in ADSCs, potentially informing strategies for adipose tissue regeneration.
