10 citations
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April 2020 in “Clinics in Dermatology” This case report describes a girl in China with biotinidase deficiency confirmed by genetic mutations, whose skin and hair symptoms improved with biotin therapy.
March 2014 in “CRC Press eBooks” Some nutrients and antioxidants may improve skin and hair health, but more research is needed to confirm these benefits.
This study reviews existing literature on regenerative therapy for androgenetic alopecia, highlighting that integrating growth factors, biotin, D-pantenol, and other active ingredients using the Vittahair protocol may enhance hair follicle regeneration, increase hair density, and improve hair quality, providing a precise and evidence-based treatment alternative.
July 2026 in “IntechOpen eBooks” This research highlights the crucial roles of B vitamins in metabolism, neurological processes, and DNA functions, and describes emerging therapies that enhance vitamin absorption and therapeutic potential.
6 citations
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May 2018 in “Plant Cell, Tissue and Organ Culture (PCTOC)” This study found that adjusting plant growth conditions, such as the use of elicitors like yeast extract and methyl jasmonate, increased wedelolactone production in Eclipta alba cell suspension culture.
November 2022 in “Journal of the Endocrine Society” In this case study, biotin supplementation was reported to interfere with free testosterone assay results, leading to falsely low readings in a postmenopausal woman with hyperandrogenism.
13 citations
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August 2020 in “Journal of Laparoendoscopic & Advanced Surgical Techniques” This study found that temporary hair loss is common after laparoscopic sleeve gastrectomy, and biotin supplementation showed low effectiveness in preventing this hair loss.
1 citations
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June 2019 in “Current developments in nutrition” This study observed that a combination of arginine silicate complex and magnesium biotinate significantly improved hair and nail growth in rats.
In this study, biotin supplementation was found to significantly increase wool follicle viability and metabolic activity in vitro, with the highest effects observed at 0.5 mg L⁻¹ concentration.
1 citations
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January 2018 in “Journal of cosmetology & trichology” This study found that a new hair loss lotion containing various cosmetic ingredients significantly increased total hair fibers and anagen hairs in individuals with androgenetic alopecia and telogen effluvium, while also improving visual hair characteristics and receiving positive user feedback without adverse effects.
57 citations
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February 2018 in “Journal of the American Academy of Dermatology” This review critiques the unwarranted promotion of biotin for hair and nail improvements, noting the lack of evidence for routine use and highlighting concerning trends in consumer and physician practices.
78 citations
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January 2017 in “Skin appendage disorders” This review discusses the use of biotin for hair and nail growth, noting clinical improvement in cases with existing pathologies, but concludes there is insufficient evidence supporting its benefits for healthy individuals.
16 citations
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January 2012 in “Asian pacific Journal of Tropical Biomedicine” This study found that a 2% polyherbal phyto-complex cream containing aqueous extracts of Trichosanthes cucumerina and Abrus precatorius effectively promoted hair growth in preclinical tests, comparable to minoxidil 2%.
5 citations
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March 2021 in “International Journal of Dermatology” This study found that adding 10 mg/day of biotin to isotretinoin treatment for acne improved hair growth and maintained skin hydration, potentially reducing isotretinoin's mucocutaneous side effects.
4 citations
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January 2015 in “Journal of microbial & biochemical technology” In this study, the researchers observed that biotin administration in biotin-deficient children with alopecia eliminated certain membrane proteins from their blood, suggesting that biotin might regulate these proteins' expression.
3 citations
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January 2017 in “Journal of cosmetology & trichology” In this clinical trial, supplementation with Lambdapil® Anti Hair Loss capsules for 6 months significantly improved hair resistance and volume in women and increased the anagen/telogen hair ratio in men, indicating enhanced hair growth compared to the placebo group.
2 citations
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January 1997 in “Journal of Clinical Biochemistry and Nutrition” This study found that germ-free mice on a biotin-deficient diet exhibited significant weight loss and severe alopecia, unlike conventional mice on the same diet.
2 citations
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August 2020 in “JCRPE” This case report describes a girl with Denys-Drash syndrome misdiagnosed with hyperandrogenism due to biotin interference in immunoassays, highlighting the need for awareness of laboratory result discrepancies.
September 2025 in “Journal of Pakistan Association of Dermatologists” This study compared the effectiveness of adding Biotin supplements to PRP treatment against using PRP alone for androgenetic alopecia patients and found no additional benefits in hair regrowth when Biotin was included.
August 2023 in “Natural Resources for Human Health” This paper offers a detailed overview of B vitamins, detailing their importance for energy, cognition, and metabolism, conditions leading to their deficiencies, symptoms of deficiencies, and the foods rich in these essential nutrients.
September 2022 in “Farmacja Polska” This review discusses the role of biotin in enzyme function and its effects on hair, skin, and nail health, noting that significant improvements are mostly seen in people with biotin deficiency, and reports no new clinical results.
82 citations
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August 2017 in “Cell Reports” This study found that antibiotic-induced gut dysbiosis, particularly overgrowth of Lactobacillus murinus, can lead to hair loss in mice by depleting biotin.
11 citations
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February 2019 in “Journal of Cosmetic Dermatology” This study found that male androgenetic alopecia patients had significantly lower serum zinc levels and suboptimal biotin levels compared to healthy controls, suggesting the potential value of zinc and biotin supplementation.
4 citations
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August 2018 in “Journal of The American Academy of Dermatology” This response article concurs with Dr. Lipner's critique that biotin supplementation is largely unsupported for routine use in dermatological conditions, with evidence mostly limited to case reports.
2 citations
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December 2014 This review discusses the role of biotin in metabolism and the consequences of its deficiency, reporting no new clinical results.
In this study, GV-350 treatment over three months improved iron status and reduced the impact of Telogen Effluvium on quality of life among 20 iron-deficient women, with no adverse events reported.
September 2023 in “Clinical, cosmetic and investigational dermatology” In this study, the researchers found that a 28-day topical treatment with a postbiotic ferment complex notably altered the scalp microbiome in women with sensitive scalps, increasing certain bacterial species and decreasing others, while also reportedly alleviating symptoms of sensitive skin syndrome in all participants.
11 citations
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September 2016 in “Journal of virological methods” In this study, rabies virus antigens were detected in the outer root sheath of the follicle-sinus complex in the muzzle skin of rabid dogs, suggesting its usefulness as an alternative diagnostic specimen.
6 citations
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May 2020 in “Pharmacology Research & Perspectives” This study in rats found that a new hydroxypropyl-β-cyclodextrin formulation of minoxidil reduced the adverse cardiovascular and proliferative effects seen with traditional minoxidil solutions.
5 citations
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June 2022 in “Frontiers in immunology” This study observed that expanding regulatory T cells in the skin of mice with alopecia areata did not reverse the condition, indicating that additional immunotherapy may be necessary.