1 citations
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February 2022 in “Journal of the American Academy of Dermatology” This review discusses biotin supplementation for dermatological conditions and highlights the lack of strong evidence supporting its efficacy, as well as the potential for laboratory testing interference.
1 citations
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February 2022 in “Biological Trace Element Research” In this animal study, applying a combination of inositol-stabilized arginine silicate complex and magnesium biotinate promoted hair growth but not nail growth.
August 2026 in “Bulletin of the Medical Institute of Continuing Education” This observational study found that a high-dose biotin regimen of 10,000 mcg/day reduced hair loss and improved hair and scalp conditions in female patients with androgenic alopecia, with effects lasting beyond treatment discontinuation, warranting further investigation into biotin's role in combination therapy.
January 2021 in “Journal of clinical & experimental dermatology research” This study found that a high dose of LustrivaTM, containing biotin and silicon, significantly increased hair thickness and reduced facial wrinkle depth in women with thinning hair compared to a placebo, without any reported adverse events.
August 2022 in “Journal of the American Academy of Dermatology” This review discusses the risk factors, clinical presentation, diagnosis, and management of dermatoses linked to B-complex vitamin deficiencies, including biotin, but does not address risks from over-supplementation.
40 citations
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August 2018 in “Skin appendage disorders” This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.
3 citations
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April 2022 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses evidence-based complementary strategies for enhancing hair regrowth after post-COVID-19 telogen effluvium and reports no new clinical results.
August 2025 in “International Journal for Vitamin and Nutrition Research” This review highlights the important role of the vitamin B complex in enhancing tissue repair, reducing inflammation, and improving surgical outcomes in plastic and reconstructive procedures by supporting cellular processes such as mitochondrial efficiency, neurotransmitter biosynthesis, and wound healing pathways.
January 2023 in “Dermatologìâ ta venerologìâ” This study found that using a combination of "Volvit tablets" (biotin 5 mg) and "Volvit intensive care shampoo" with biotin in patients with diffuse telogen alopecia stopped hair loss and restored hair follicles to normal function, suggesting effectiveness and safety for wide clinical use.
August 2021 in “Journal of the American Academy of Dermatology” This study reported that an anti-hair loss shampoo containing six active ingredients activated the Wnt/β-catenin pathway in human hair follicle dermal papilla cells in vitro.
7 citations
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June 2018 in “Journal of the American Academy of Dermatology” This article reviews uncombable hair syndrome, highlighting its symptoms, potential diagnosis methods, and the suggestion for biotin supplements, but it reports no new empirical results.
1 citations
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January 2011 in “The annals of clinical and analytical medicine” This study observed that a mesotherapy formulation was associated with statistically significant improvements in hair quantity, thickness, and scalp condition among 23 patients with androgenetic alopecia, without noted side effects.
January 2020 in “Journal of dermatology research and therapy” This study reviews popular over-the-counter hair loss products available online but reports no new clinical results.
June 2023 in “JAAD international” This report highlights that 49.4% of U.S. patients with skin issues use complementary and alternative medicine (CAM), with 6% leveraging it specifically for their skin conditions, including treatments like herbal, vitamin, and mineral supplementation for alopecia.
January 1990 in “대한피부과학회지” This study found that peanut agglutinin binding patterns after neuraminidase pretreatment can help differentiate malignant melanoma from nevocellular nevus in skin specimens.
27 citations
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July 1946 in “The journal of nutrition/The Journal of nutrition” This study found that adding inositol or biotin to a pig's diet without sulfathalidine had no effect on growth or feed efficiency, but both helped alleviate deficiency symptoms caused by sulfathalidine.
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that a shampoo containing a 6-active ingredient complex increased β-Catenin production in human hair follicle dermal papilla cells to levels comparable to Finasteride, suggesting potential for promoting hair growth. It also showed good cleaning efficacy, volume, and shine in a sensorial study.
26 citations
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May 1984 in “Journal of Parenteral and Enteral Nutrition” In this study, a 54-year-old woman with short bowel syndrome developed biotin deficiency and associated symptoms while on home parenteral nutrition lacking biotin, which improved significantly after supplementation.
January 2014 in “Journal of Pigmentary Disorders” This review discusses age-related and environmental factors affecting scalp hair changes in women, highlighting diagnostic complexities and ongoing research into targeted treatments, without reporting new clinical results.
89 citations
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January 2020 in “PubMed” This review discusses biotinidase deficiency, noting that biotin treatment from birth can prevent symptoms, but acknowledges the complexity and need for further understanding due to late-onset cases with varied clinical findings.
11 citations
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January 1989 in “PubMed” This study reported that biotin treatment improved or cured fur and skin conditions in most dogs, though the response varied by breed.
5 citations
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August 2017 in “The Journal of Clinical Psychiatry” In this letter, excessive hair loss due to telogen effluvium was observed as a distressing side effect in the early months of valproate treatment, potentially linked to disruption in biotin metabolism, although the exact mechanism remains unclear.
2 citations
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January 2019 in “Elsevier eBooks” This review discusses biotin's role in nutrition and suggests no benefit to supplementing it for hair, nails, and skin in healthy individuals; it reports preliminary findings that high dosages may help some multiple sclerosis patients.
May 2023 in “Elsevier eBooks” This source highlights the increasing use of nutritional supplements among patients with androgenetic alopecia, noting positive effects on hair thickness and density in controlled trials, while emphasizing the need for further research to understand their safety and efficacy.
January 2011 in “Springer eBooks” Eating a balanced diet with the right vitamins and minerals is important for healthy hair, but too many supplements can be harmful.
July 2025 in “Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria” This study reviewed various supplements for treating androgenetic alopecia and found that Serenoa repens shows the strongest evidence for use as a single treatment, while ketoconazole may help as an adjunct. Other supplements like zinc, vitamin D, and biotina are not recommended unless deficiencies exist.
1 citations
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June 2017 in “Journal of The American Academy of Dermatology” PRP treatment for hair loss shows promise, with 58% of patients satisfied and most noticing improvement within 6 months.
August 2021 in “Indian dermatology online journal” This study reported an unusual case of nail matrix involvement and trachyonychia in a child with juvenile pityriasis rubra pilaris, showing significant improvement with topical therapy and oral biotin.
January 2016 in “Journal of Cosmetics, Dermatological Sciences and Applications” In this study, four months of twice-daily application of A100 gel significantly increased hair growth in men with androgenic alopecia, with no reported side effects.
5 citations
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December 1942 in “Journal of the American Medical Association” This article reviews the classification and characteristics of water soluble vitamins, focusing on their varying solubility and functions, and reports no new experimental findings.