Hair Cross-Sectioning in Uncombable Hair Syndrome: An Easy Tool for Complex Diagnosis

Uncombable hair syndrome (UHS) was a rare genetic disorder characterized by unruly, straw-like hair that resisted combing, typically presenting in early childhood. The hair had a unique kidney-like or triangular shape in cross-section, which contributed to its rigidity. Diagnosis was traditionally confirmed through expensive scanning electron microscopy, but the study suggested that hair cross-sectioning could be a simpler, cost-effective diagnostic tool. UHS usually improved before puberty, and biotin supplements were recommended to aid this process. Excessive brushing was discouraged to prevent further hair damage.