Original Article: The Significance of Peanut Agglutinin in the Differential Diagnosis of Nevus Cell Nevus and Malignant Melanoma

    January 1990 in “ 대한피부과학회지 ”
    정진영, 문두찬, 권경술, 정태안
    TLDR Peanut agglutinin staining helps differentiate malignant melanoma from nevocellular nevus.
    The study investigated the use of peanut agglutinin (PNA) staining, following neuraminidase pretreatment, to differentiate between nevocellular nevi and malignant melanomas. In normal skin, PNA staining was observed in the epidermis, hair follicle epithelium, and sebaceous glands, but not in sweat ducts. Nevocellular nevi showed no PNA staining, whereas malignant melanomas exhibited PNA staining along the cell membrane. This indicated that PNA staining after neuraminidase pretreatment could be a useful tool for distinguishing between malignant melanoma and nevocellular nevus.
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