Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that nicotine may have a therapeutic role in mitigating the exacerbation of infertility conditions connected with alpha-synuclein-related Parkinson’s disease through molecular interactions identified via pathway analysis.

This study suggests that polygonum multiflorum may treat androgenic alopecia by mediating the PI3K/Akt pathway to regulate apoptosis, inhibit inflammation and oxidative stress, and induce melanin production.

This study identified four hub genes that are closely linked to the causative factors of androgenetic alopecia, suggesting potential diagnostic and therapeutic targets.

This review explains methods for studying chromatin variation at the single-cell level using scATAC-seq and discusses integrating these measures with other omics platforms but reports no new results.

This research reported that melatonin may serve as a potential treatment for both rosacea and Alzheimer's disease by regulating inflammation and vascular signaling pathways, demonstrating effectiveness in reducing symptoms associated with rosacea-like skin lesions in experimental settings.

This review explores the potential use of plucked hair follicles in regenerative medicine and diagnostics but presents no new research findings.

This study found that tdDPC-EVs significantly improved wound healing by enhancing angiogenesis through the KLF4/VEGFA axis, offering advantages over traditional DPC-EVs.

This study identified core genes and pathways involved in androgenetic alopecia, finding that genes related to hair follicle development are down-regulated, while those linked to immune responses are up-regulated, highlighting potential therapeutic targets.

This study highlights the role of bioinformatics and in-silico studies for identifying drug targets, specifically in herbal drugs, using software and modern techniques to analyze data and model disease pathways before later-stage in vivo and in vitro testing.

This study identified five potential molecular targets for future androgenetic alopecia therapy using genome-wide gene-expression investigations and bioinformatics analyses.

This study found a recurrent nonsense mutation in the HR gene linked to atrichia with papular lesions in two Kashmiri families, suggesting whole exome sequencing as an efficient method for diagnosis and genetic counseling.

In this study, 20% whale oil applied to mice was observed to promote hair growth more effectively than a control or 3% minoxidil, showing increased hair follicles and thicker subcutaneous tissue.

This article describes how PESCADOR software assists in creating detailed biological pathway charts from PubMed abstracts, focusing on hair and breast development case studies without providing new clinical results.

This narrative review found that while AI-based tools in dermatology, particularly for hair disorder assessment, have potential to enhance clinical practice by improving objectivity and personalization, they currently serve mainly a complementary role and face challenges like methodological limitations and data bias.

This study identified three hub genes—BMP4, POSTN, and WNT5A—that are closely associated with keloid fibroblast hyperplasia, suggesting they may serve as potential biomarkers for inhibiting this condition. Further research is necessary to fully understand their roles in keloid development.

This study found that tofacitinib led to ≥50% hair regrowth in eight out of twelve patients with moderate to severe alopecia areata, suggesting a potential benefit for using JAK inhibitors in treating this condition.

This study identified a coexpression network and key genes associated with thyroid eye disease, potentially aiding in its treatment and diagnosis.

This review discusses how targeting protein degradation processes may help overcome cancer drug resistance, but reports no new clinical results and suggests further research for precise therapeutic strategies.

This review suggests that hyperspectral and terahertz imaging show promise in non-invasively assessing scalp changes associated with hair loss, but further validation is needed for clinical application.

This study found that secretory proteins in DFCM play crucial roles in regulating nerve restoration by forming significant protein interaction networks during the wound repair process.

This study constructed a model using serum levels of BMP2, CD8A, PRF1, and XCL1 as a non-invasive biomarker to accurately predict recurrence in patients with alopecia areata.

This study suggests that hydroxytyrosol may influence inflammation and oxidative stress pathways in androgenetic alopecia, particularly through interaction with the PTGS2 gene, warranting further experimental validation.

This study explored the molecular mechanisms by which Polygonum multiflorum may treat androgenic alopecia, suggesting it influences cell apoptosis and inflammation through specific pathways, with potential application value pending further testing.

In this study, researchers used transcriptome sequencing and bioinformatics analysis to identify important genes and pathways involved in the transition between hair growth phases, offering new insights into hair follicle cycle regulation and development.

This study identified four immune-related signaling molecules (LGR5, PTN, JAG1, and DKK1) associated with keloid, suggesting their potential role in its pathogenesis and as targets for new treatments.

This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.

This study observed that both ritlecitinib and brepocitinib improved scalp biomarkers in patients with alopecia areata, with associations to hair regrowth seen in this phase 2a trial.

This study used bioinformatics to explore molecular differences in testicular and ovarian responses to SARS-CoV-2, identifying genes that could be associated with sex differences in infection outcomes.

This review discusses various applications of CRISPR-based tools in cancer research, emphasizing their potential for investigating microRNA functions and developing microRNA-based therapies, despite challenges like off-target effects and delivery issues in using CRISPR/Cas9.

This study introduces MicrobeFDT, a tool that clusters chemically similar compounds and links them to gut microbial enzymes and toxicities, demonstrating its utility by uncovering previously unknown metabolism of the cancer drug altretamine.