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Glossary Bioinformatics

use of computational tools to analyze biological data

Bioinformatics is an interdisciplinary field that combines biology, computer science, and information technology to analyze and interpret biological data, such as genetic sequences. It involves the use of software tools and algorithms to understand complex biological processes, which can be crucial for research in areas like genomics, drug discovery, and personalized medicine.

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research GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk

57 citations , November 2017 in “Nature Communications”

This genome-wide association study identified 71 genetic loci linked to male pattern baldness, with 30 novel loci, explaining 38% of the risk and suggesting shared pathways with lifespan and cancer traits.

research Drug repositioning: current approaches and their implications in the precision medicine era

42 citations , January 2018 in “Expert review of precision medicine and drug development”

This review discusses the integration of drug repurposing with personalized medicine through off-label prescribing and reports no new results, highlighting the potential for systematic exploration using omics technologies.

research Proteomics as a tool to improve novel insights into skin diseases: what we know and where we should be going

3 citations , October 2022 in “Frontiers in Surgery”

This review discusses the role of proteomics in understanding skin diseases such as cancers and psoriasis, with findings suggesting cell death and metabolism as major areas of focus, but reports no new experimental results.

research MiR‐200c‐3p as a novel genetic marker and therapeutic tool for alopecia areata

7 citations , March 2024 in “Skin Research and Technology”

This study identified miR-200c-3p as influencing key genes in the EGFR resistance pathway, suggesting its potential theranostic role in addressing issues related to this pathway.

TNC+ Fibroblasts Involved in Skin Inflammation via Neuro-Immune Interactions with T Cells

research TNC+ fibroblasts involve in skin inflammation via neuro-immune and interacting with T cells

September 2023 in “Research Square (Research Square)”

This study found that TNC + fibroblasts are crucial in neuro-immune interactions in various skin diseases, particularly inflammation and tumors, by engaging extensively with immune cells and overexpressing inflammatory genes, suggesting their significant role in skin abnormalities.

research Knowledge Mapping of Drug Repositioning’s Theme and Development

5 citations , April 2023 in “Drug Design Development and Therapy”

This article discusses the increasing trend of retargeting existing drugs for new indications and emphasizes the need for additional support in drug development, without reporting specific new results.

research Pharmacological Effects of Natural Compounds Extracted from Urtica dioica Evaluated by in Silico and Experimental Methods

3 citations , October 2018 in “Revista de Chimie”

This review discusses the potential medicinal properties and pharmacokinetic features of nettle compounds ursolic acid and quercetin, highlighting quercetin as a promising candidate for antioxidant and anti-aging effects, but reports no new clinical results.

research PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker Discovery

110 citations , February 2024 in “Journal of Chemical Information and Modeling”

This study describes the PandaOmics platform, which uses AI and bioinformatics to identify new therapeutic targets and biomarkers for various diseases, demonstrating validation in laboratory and animal studies.

research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

In this in silico study, researchers analyzed nonsynonymous SNPs in the LIPH gene linked to hypotrichosis and identified three potentially harmful variants (W108R, C246S, and H248N) out of 215 total, using sequence- and architecture-based bioinformatics techniques to differentiate between harmful and benign SNPs.

research Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients

82 citations , September 2020 in “Briefings in Bioinformatics”

This study identified shared genes and pathways in idiopathic pulmonary fibrosis patients with COVID-19, suggesting these may increase mortality and pointing to potential drug targets for treatment.

research An in silico approach to the identification of potential proteomic and genomic diagnostic biomarkers for primary cicatricial alopecia

October 2021 in “Experimental Dermatology”

This study explores the use of in silico methods to identify potential diagnostic biomarkers for primary cicatricial alopecia, revealing significant interactions among genes and proteins related to disease pathogenesis.

research Network pharmacology and molecular docking analysis on potential molecular targets and mechanism of action of BRAF inhibitors for application in wound healing

11 citations , June 2023 in “Journal of Cellular Biochemistry”

This study suggests that BRAF inhibitors, particularly Encorafenib and Dabrafenib, may have potential applications in wound healing by targeting specific proteins involved in the healing process in murine models.

research Molecular cloning and characterization analysis of LEF-1 gene from Inner Mongolia Cashmere Goat

1 citations , October 2010 in “2010 3rd International Conference on Biomedical Engineering and Informatics”

This study successfully cloned and characterized the LEF-1 gene from Inner Mongolia Cashmere Goats, potentially aiding efforts to enhance cashmere production through genetic modification.

Analysis of Keratin-Associated Protein-7 (KRTAP7) Structure and Function in Indian Dromedary Camel

research Analysis of Keratin-Associated Protein-7 (KRTAP7) protein structure and function in Indian dromedary camel (Camelus dromedarius)

March 2026 in “The Indian Journal of Animal Sciences”

This study on Indian dromedary camel breeds investigated the KRTAP7 protein, finding all four breeds shared an identical gene sequence, with 13 phosphorylation and glycosylation sites influencing hair characteristics, alongside predicted interactions with other biosynthesis-related proteins.

research A Perspective on RNAi-Based Biopesticides

140 citations , February 2020 in “Frontiers in Plant Science”

This article discusses the potential of RNA-based biopesticides for sustainable agriculture and reports no new experimental results; it highlights the need for improved delivery systems and regulatory development to enhance deployment.

research Application of multi-omics techniques to androgenetic alopecia: Current status and perspectives

June 2024 in “Computational and Structural Biotechnology Journal”

This review discusses the integration of omics analyses in androgenetic alopecia research, reporting no new clinical results but suggesting that collaborative multi-omics studies may enhance understanding of AGA's pathomechanisms.

research Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

July 2020 in “Bioinformatics and Bioengineering”

This study found that multiple genes and pathways, particularly several keratin-associated proteins, may be involved in the molecular pathogenesis of male androgenetic alopecia.

research Differential Expression of Proteins Associated with the Hair Follicle Cycle - Proteomics and Bioinformatics Analyses

10 citations , January 2016 in “PLOS ONE”

This study investigated protein expression changes during mouse hair follicle cycles and suggested their involvement in biological networks, potentially identifying targets for hair disease therapy.

research Impact of taxol on dermal papilla cells — A proteomics and bioinformatics analysis

9 citations , October 2011 in “Journal of proteomics”

This study found that taxol induces apoptosis in dermal papilla cells, affecting protein expression related to biological processes and potentially contributing to taxol-induced alopecia.

Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target

research Bioinformatics analysis of genes associated with the patchy-type alopecia areata: CD2 may be a new therapeutic target

4 citations , September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

This study found that CD2 could be a potential new therapeutic target for treating patchy-type alopecia areata, suggesting the need for further research into its role.

research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

January 2023 in “Research Square (Research Square)”

This study identified m6A-related genes, particularly IGF2BP3, as significantly up-regulated in keloid patients, potentially implicating them in the condition's molecular mechanisms and suggesting targets for therapy.

Human Gene Correlation Analysis: A Tool for the Identification of Transcriptionally Co-Expressed Genes

research Human gene correlation analysis (HGCA): A tool for the identification of transcriptionally co-expressed genes

24 citations , June 2012 in “BMC Research Notes”

This study outlines the Human Gene Correlation Analysis tool, which classifies human genes by coexpression levels and identifies overrepresented annotation terms in correlated gene groups, with no new clinical results reported.

research Transcriptional Profiling in Rat Hair Follicles following Simulated Blast Insult: A New Diagnostic Tool for Traumatic Brain Injury

10 citations , August 2014 in “PLoS ONE”

This study suggests that mammalian hair follicles may serve as a viable and non-invasive system for diagnosing traumatic brain injury, reflecting similar molecular responses observed in other tissues.

research Identification of key genes induced by platelet-rich plasma in human dermal papilla cells using bioinformatics methods

16 citations , December 2016 in “Molecular Medicine Reports”

This study found that platelet-rich plasma may influence the proliferation of human hair dermal papilla cells by affecting gene expression related to the cell cycle.

Functional Analysis of the PIP5K1A Gene in Liaoning Cashmere Goats: An Investigation Based on Bioinformatics, Tissue Localization, and Biological Functions

research Functional analysis of the PIP5K1A gene in Liaoning Cashmere goats: an investigation based on bioinformatics, tissue localization, and biological functions

January 2025 in “Cellular and Molecular Biology”

This study found that in Liaoning cashmere goats, overexpression of the PIP5K1A gene enhances skin fibroblast proliferation, while interference with this gene reverses melatonin-induced proliferation, and PIP5K1A regulates certain miRNA expressions, suggesting a role in improving cashmere yield and quality.

Identification of Potential Key Genes and Pathways Associated with the Pashmina Fiber Initiation Using RNA-Seq and Integrated Bioinformatics Analysis

research Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis

36 citations , January 2021 in “Scientific Reports”

This study identified key genes and signaling pathways involved in the growth phases of Pashmina goat hair follicles, highlighting the role of several gene families and transcription factors in fiber quality and growth regulation.

Mechanism of Traditional Chinese Medicine in the Treatment of Ischemic Stroke by Intervening Ferroptosis Pathway Based on Molecular Target Prediction and Bioinformatics

research Mechanism of traditional Chinese medicine in the treatment of ischemic stroke by intervening ferroptosis pathway based on molecular target prediction and bioinformatics

January 2024 in “Research Square (Research Square)”

This study identified key genes related to ischemic stroke through the ferroptosis pathway and highlighted the potential role of specific traditional Chinese medicines in regulating associated biological processes.

research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

8 citations , March 2023 in “International Wound Journal”

The researchers reported that several m6A-related genes, particularly IGF2BP3, were differentially expressed in keloid tissue compared to normal skin, indicating potential targets for understanding keloid pathogenesis and treatment.

research Evaluating statistics in clinical trials: Making the unintelligible intelligible

5 citations , October 2008 in “Australasian Journal of Dermatology”

This review aims to help medical practitioners understand inferential statistical methods to critically evaluate clinical trial design and analyses, but it doesn’t present new research findings.

research Human Hair as a Testing Substrate in the Era of Precision Medicine: Potential Role of ‘Omics-Based Approaches

1 citations , December 2018 in “IntechOpen eBooks”

This review discusses the potential of using human hair proteomics for non-invasive diagnostic and forensic applications but reports no new results; the authors highlight areas needing further research.