Bioinformatic Network Analysis on the Molecular Interactions Between Parkinson’s Disease, Alpha-Synuclein, and Infertility Condition

September 2023 in “ Middle East Fertility Society Journal ”

Velu Krishnan, Shivani Patel, Priyanka Shenoy, Jessica Cottrell

dihydrotestosterone caspases alpha-synuclein nicotine DHT

TLDR Nicotine may help treat both Parkinson's disease and infertility.

This study investigates the molecular interactions between Parkinson's disease (PD), characterized by alpha-synuclein (SNCA) abnormalities, and infertility conditions (IC) using bioinformatic network analysis. It identifies 12 overlapping molecules between SNCA and IC, suggesting a connection between these conditions. The research highlights the roles of dihydrotestosterone (DHT) and caspases, with SNCA activation potentially exacerbating both PD and IC. Nicotine is identified as a potential therapeutic agent, as its activation within the molecular network led to a downregulation of both PD pathology and IC. The study suggests a novel link between infertility and genes associated with SNCA-related PD, emphasizing nicotine's potential therapeutic role.

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