Proof-Of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson's Disease

This study investigated inflammasome signaling proteins as potential biomarkers for the inflammatory response in Parkinson's disease (PD). By analyzing plasma from PD subjects and healthy controls, researchers found that levels of inflammasome proteins, including caspase-1, ASC, and IL-18, were elevated in PD patients. These proteins were identified as promising biomarkers of inflammation in PD. The study also showed that inflammasome proteins significantly contribute to and predict IL-18 levels in PD patients, suggesting their potential role in PD diagnosis and treatment.