Transcriptomic Analysis of Regulatory Mechanisms in the Telogen-Anagen Transition of Ovine Hair Follicles

December 2024 in “ BMC Genomics ”

Ningyue Zhang, Yifan Wang, Jiankui Wang, Liang Zhang, Haoran Sun, Xiaochun Yuan, Siyu Wang, Chunguang Wang, Xinhai Li

telogen phase anagen phase hair follicles transcriptome sequencing bioinformatics analysis hair follicle cycle hair growth regulation hair growth hair cycle

TLDR Key genes and pathways control sheep hair growth phases.

This study examines the regulatory mechanisms in the telogen-anagen transition of ovine hair follicles in Dorper sheep, focusing on shedding and non-shedding phenotypes. Seventeen ewes were analyzed, revealing 2,536 differentially expressed genes and emphasizing the role of the Wnt/β-catenin signaling pathway and keratins in hair growth. Shedding sheep displayed distinct hair follicle cycles, while non-shedding sheep showed slower growth without a cycle. The research identifies key genes and pathways, such as CCNA2, LEF1, NF-κB, PI3K-Akt, and JAK-STAT, crucial for hair follicle development. These findings enhance the understanding of hair follicle cycling and may inform future research on hair growth regulation.

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