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This review highlights the potential of PROTACs to transform cancer treatment by selectively degrading oncogenic proteins, overcoming drug resistance, and reducing toxicity; it also discusses challenges in optimizing these therapies for personalized applications.

This study found that olorofim demonstrated potent in vitro and in vivo antifungal activity against dermatophytes, resolving skin lesions in a guinea pig model similar to clotrimazole, suggesting it may be a promising treatment for dermatophytosis.

This study found that methanol extracts from four natural products inhibited the growth of Vibrio vulnificus in Luria-Bertani broth, seawater, and shellfish, while also protecting HeLa cells from its cytotoxic effects, suggesting their potential as safe antimicrobial agents.

This case report from the study describes a dog suffering from dermatophytosis caused by Microsporum canis, presenting with alopecia on the neck and ear, illustrating the zoonotic risk of these fungal infections in both animals and humans, particularly in hot and humid climates.

In this study, researchers developed a wearable red and blue LED patch and a sprayable fibrin gel to treat infected wounds at home, demonstrating effective infection control and enhanced wound healing in diabetic mice and minipigs.

This study found that Mf-rich-fiber in human hair underwent significantly greater degradation by proteases than Ma-rich-fiber, especially when treated with Proteinase K.

This study found that domestic temporary hair dyes may pose a health risk due to their cytotoxic effects on human red blood cells and NIH/3T3 cell lines.

This study found that incorporating keratin extracted from hair into NBR modestly enhanced the mechanical properties and biodegradability of the rubber.

In this study, dynamic hyaluronic acid hydrogels with properties like injectability and controlled degradation were developed to enhance healing and remodeling of diabetic wounds, achieving effects such as inflammation reduction, increased angiogenesis, and neovascularization, leading to complete wound healing.

This source critically examines Bruce Ames's influential contributions to biochemistry, particularly his theories on oxidative stress and mitochondrial DNA damage in aging, while acknowledging current challenges to his work and highlighting his lasting impact on the fields of mutagen screening and public health.

Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.

This study describes a gel-supported in vitro system for culturing skin samples that may effectively replace animal systems for toxicity testing, showing high correlation with in vivo skin toxicity measurements.

This study examined the use of emulsifiers and preservatives in soft emulsion-type drugs, suggesting that biogenic surfactants could be promising alternatives to synthetic agents that often cause side effects.

This review highlights how wound microbiota, particularly bacteria like Staphylococcus epidermidis and Staphylococcus aureus, significantly influences wound healing dynamics and suggests potential clinical applications through microbiota manipulation.

This study observed that biodegradable PVA/agar films with incorporated Achillea millefolium L. essential oil, especially at 1% (v/v), demonstrated good mechanical performance and selective antibacterial activity against E. coli, suggesting their potential as wound dressings.

Photobiomodulation helps protect hair follicle cells from damage caused by DHT.

This review reports that natural compounds show promise in slowing skin photoaging by targeting cellular pathways in keratinocytes and fibroblasts. However, comprehensive clinical studies are needed to verify their efficacy and safety.

This study developed a novel mineralization strategy using metal-polyphenol coordination for dynamic control of nano-scale processes, enhancing hydrogels that support wound healing with antibacterial and angiogenesis-promoting properties.

This review discusses two approaches to address aging: a tactical method to delay and slow age-related issues, and a strategic method aiming to eliminate aging altogether by targeting its root cause.

Modifying gut bacteria with pro- and postbiotics may help treat hair loss.

This case study of three siblings highlights the importance of recognizing dermatologic signs—alopecia and periorificial dermatitis—for early diagnosis and treatment of biotin-responsive multiple carboxylase deficiency.

This study found that upcycled postbiotic cell-free supernatants from Limosilactobacillus fermentum MG901 and MG4237 protected human dermal papilla cells from oxidative stress, enhancing wound-healing capacity and mitochondrial function, suggesting potential as a sustainable cosmetic ingredient for hair loss alleviation.

This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.

This article argues that esthetic dermatology could benefit from a more biologically informed approach through the integration of advanced biomarkers and imaging technologies, but cautions that many tools are not yet fully validated for clinical use.

This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.

In this study, researchers isolated and identified diverse endophytes from plants in Asia, finding that these microorganisms have significant potential for producing useful metabolites, including enzymes and antibiotics.

This study found that dual inhibition of BACE1 and BACE2 in mice affects melanosome maturation and causes dose-dependent hair depigmentation without altering retinal morphology.

This study suggests that tailoring burn wound treatment to the timing of prevalent cell death types could improve therapy outcomes, as autophagy and apoptosis show distinct temporal patterns post-burn in a rat model.

This review discusses surface engineered metal-organic frameworks for wound healing and reports no new clinical results; it highlights their potential as antibacterial agents, therapeutic delivery systems, and wound dressings.

This study introduces a new multiaxial bioreactor system that uniformly stretches tissue-engineered skin grafts and improves skin tissue maturation through enhanced cellular distribution and environmental monitoring.