Alopecia and Periorificial Dermatitis in Biotin-Responsive Multiple Carboxylase Deficiency

July 1983 in “ Journal of the American Academy of Dermatology ”

Mary L. Williams, Seymour Packman, Morton J. Cowan

alopecia biotin multiple carboxylase deficiency periorificial dermatitis enzyme deficiency hair loss biotin supplementation

Studysummary This case study of three siblings highlights the importance of recognizing dermatologic signs—alopecia and periorificial dermatitis—for early diagnosis and treatment of biotin-responsive multiple carboxylase deficiency.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discussed a case of biotin-responsive multiple carboxylase deficiency, which was associated with symptoms of alopecia and periorificial dermatitis. This condition was characterized by a deficiency in multiple carboxylase enzymes, which are crucial for various metabolic processes. The study highlighted that biotin supplementation effectively alleviated the symptoms, indicating the importance of biotin in managing this deficiency. The findings underscored the potential for biotin therapy in treating similar cases of alopecia and dermatitis linked to enzyme deficiencies.

View this study on jaad.org →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Biotin-Responsive Alopecia and Developmental Regression

74 citations , July 1979 in “Lancet”

This case report describes a 10-month-old boy with dermatitis, alopecia, and hypotonia who showed dramatic improvement with oral biotin, suggesting a possible defect in biotin absorption or transport.

research Acquired Zinc Deficiency in Long-Term Parenteral Nutrition: A Case Study

73 citations , May 1976 in “JAMA”

This case report associates severe zinc deficiency with long-term total parenteral nutrition, suggesting the need for trace element supplementation in such nutritional management.