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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Noggin is necessary to start the hair growth phase in skin after birth.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Testosterone may slow down wound healing and increase inflammation.

Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

Androgen self-administration might be controlled by membrane receptors, not nuclear ones.

Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

Using defensins to activate stem cells may improve skin aging signs without causing inflammation.

Flutamide, an antiandrogen, has minimal impact on female rat endocrine systems and does not significantly change their reproductive cycles.

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.

Clascoterone may be a promising treatment for hair loss.

Old drugs like finasteride and spironolactone are being successfully used for hair loss and skin conditions, and many other drugs show promise for new uses in dermatology.

A protein combining parathyroid hormone and collagen helped hair regrow in mice with a hair loss condition.

Human skin can make serotonin and melatonin, which help protect and maintain it.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

New treatments for male hypogonadism are effective and should be personalized.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

Current and future treatments for alopecia areata focus on immunosuppression, immunomodulation, and protecting hair follicles.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

Dihydrotestosterone (DHT) stops hair growth in mice by lowering a growth factor important for hair.