Stem Cells in Dermatology and Anti-Aging Care of the Skin

    Amy Forman Taub, Kim Pham
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    TLDR Using defensins to activate stem cells may improve skin aging signs without causing inflammation.
    The document from 2018 examines the use of stem cells in dermatology for anti-aging and skin repair, focusing on the potential of defensins to activate Lgr6+ stem cells for healthier skin regeneration. It discusses the challenges associated with stem cell use, including tumorigenicity and ethical concerns. A pilot study with 22 subjects and a 12-week study with 45 subjects demonstrated that a skin care regimen with synthetic alpha-defensin 5 and beta-defensin 3 improved signs of skin aging, such as wrinkle reduction and decreased skin oil production, without causing inflammation. The treatment increased epidermal thickness and improved various skin quality metrics, although some changes were not statistically significant. The findings indicate that defensins could be a promising targeted treatment for skin aging, but more research is needed to understand their mechanisms.
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