Treatment of Alopecia Areata in Mice by Stimulating Hair Follicles Using Parathyroid Hormone Agonists Linked to a Collagen Binding Domain

January 2015 in “ Journal of clinical & experimental dermatology research ”

Ranjitha Katikaneni, Tulasi Ponnapakkam, Rohan Gulati

alopecia areata PTH-CBD parathyroid hormone collagen-binding domain hair follicles anagen VI beta-catenin Wnt pathway CD8+ cells hair loss

Studysummary This study found that treatment with PTH-CBD stimulated hair growth in mice with alopecia areata, with increased levels of beta catenin indicating activation of the Wnt pathway.

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In a 2015 study, researchers tested the effects of PTH-CBD, a fusion protein combining parathyroid hormone with a collagen-binding domain, on hair growth in 33 female C3H/HeJ engrafted mice with alopecia areata. The mice were treated subcutaneously with either a vehicle or PTH-CBD at various doses for 8 weeks. The study found that 18 out of 22 PTH-CBD treated mice maintained or regrew hair, which was significantly higher than the 4 out of 11 mice in the vehicle group. Despite an ongoing immune reaction indicated by no change in CD8+ cells, there was an increase in anagen VI hair follicles and elevated beta-catenin levels in the PTH-CBD treated mice. The study concluded that PTH-CBD treatment led to hair growth improvements by activating the Wnt pathway, suggesting its potential use in alopecia areata treatment.

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