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This study suggests that IGFBP-2 may play a role in basal cell carcinoma development by mediating epidermal progenitor cell expansion in hair follicles with activated Shh signaling.

This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.

This study found that HIF1 and mTORC1 signalling were active in both basal cell carcinoma and trichoepithelioma, but the pathways do not reliably differentiate between the two.

Krt6a-Cre transgenic mice help study gene effects on hair follicle development and tumor suppression.

This study demonstrates that α-parvin is crucial for epidermal morphogenesis and hair follicle development by mediating integrin-dependent adhesion and actin organization in keratinocytes.

This study found that keratin 15 lacks the ability to sequester YAP1 in keratinocytes effectively, unlike keratin 14, and suggests that a higher K15:K14 ratio may promote a progenitor state and inhibit differentiation in epidermal keratinocytes.

This study found that the Foxn1(-/-) nude phenotype significantly influences epithelial progeny in skin, with notable changes in stem cell niches not achievable in other models.

This study found that the phenotype of Hedgehog/Gli-driven skin tumors in mice depends on the cell of origin, tissue context, and level of oncogenic signaling.

This study found that the Notch signaling pathway is suppressed in basal cell carcinomas and highly expressed in hair follicles, suggesting it might be a target for treatment strategies.

In this study, researchers found that basal cell carcinomas with common Hedgehog signaling mutations may require additional mutations to hyperactivate downstream signaling and progress beyond dormancy.

This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.

In this study, re-activating SOX9 in adult epidermal stem cells led to a fate switch towards hair follicle stem cell identity, with altered chromatin dynamics and oncogenic activation, contributing insights into developmental processes and cancer pathways.

This study suggests that biallelic loss of the Hedgehog signaling repressor Patched alone in Keratin 5+ epidermal cells is insufficient to drive basal cell carcinoma development unless exogenous stimuli trigger accumulation of BCC precursor cells.

This study found that melatonin treatment increased epidermal thickness, subcutaneous fat, and dermal-related factors in postmenopausal rats, suggesting benefits for skin structure after menopause.

This study reported that molecules from Zebrafish embryo cell differentiation can counteract neurodegeneration, regenerate tissues, and potentially reverse hair follicle damage in androgenetic alopecia.

This narrative literature review examined how linking embryonic development with non-genetic skin anomalies can improve diagnostic accuracy, guide prenatal counseling, and enrich dermatology education by revealing specific vulnerabilities in skin morphogenesis and supporting advances in regenerative medicine.

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

This study found that synchronized signals in the microenvironment regulate stem cell lineage choices in hair follicles by influencing chromatin dynamics during regeneration.

This review discusses the multiple layers of environmental controls on hair stem cell homeostasis and suggests that targeting these layers could offer safer regenerative medicine therapies without directly using stem cells.

The researchers reported that hair follicle germinative epidermal cells can form complex structures when associating with papilla cells in culture, unlike other types of epidermal cells.

This review summarizes recent progress in human hair follicle bulge cell research, particularly the characterization and isolation of these stem cells, but reports no new experimental results.

This article discusses the structure and function of the skin, the etiology and increasing incidence of skin cancer, and the types and prevalence of malignant skin tumors, but reports no new research findings.

This study found that two short peptides derived from pigment epithelium-derived factor significantly accelerated full-thickness skin wound healing in mice through mechanisms that may involve increased cell proliferation and stem cell mobilization.

The researchers reported that in nonmelanoma skin cancers, the expression of osteopontin splice variants is significantly higher compared to normal skin, with OPN-a elevated in basal cell carcinoma more than OPN-c.

This study observed that among elderly patients, the most common systemic disease associated with skin conditions was diabetes, while wrinkling and xerosis were prevalent skin changes.

This research reports that after genotoxic stress from ionizing radiation or chemotherapy, hair follicles can utilize progenitor cells from transit-amplifying compartments, not quiescent stem cells, for repair, suggesting a potential therapeutic approach to prevent therapy-induced hair loss by activating these progenitors.

This study suggests that programmed cell death plays a crucial role in shaping the structure of the human epidermis and its appendages during development.

In this study, researchers reported that specific immunoreactivity patterns observed in hair follicle stem cell markers suggest different origins for trichilemmoma, basal cell carcinoma, and squamous cell carcinoma in human skin tissues.

This study hypothesizes that postinflammatory hyperpigmentation in ashy dermatosis may result from basal cell apoptosis, as evidenced by consistent histologic findings across nine patients.

A rare benign skin tumor showed unusual features of sebaceous and sweat glands, important for correct diagnosis.