Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors to Prevent Hair Loss from Chemotherapy or Radiation Therapy
March 2023
chemotherapy radiotherapy hair follicles genotoxic stress ectopic progenitors transit-amplifying cells low-dose ionizing radiation high-dose ionizing radiation basal hair bulb progenitors hair matrix cells outer root sheath cells stem cell-like state WNT signaling p53 cyclophosphamide chemo radiation therapy hair roots stress from toxins progenitor cells TAC low-dose IR high-dose IR hair bulb cells hair matrix outer root sheath stem cells WNT pathway p53 protein Cytoxan
Studysummary This research reports that after genotoxic stress from ionizing radiation or chemotherapy, hair follicles can utilize progenitor cells from transit-amplifying compartments, not quiescent stem cells, for repair, suggesting a potential therapeutic approach to prevent therapy-induced hair loss by activating these progenitors.
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