Pigment Epithelium-Derived Factor Short Peptides Facilitate Full-Thickness Cutaneous Wound Healing by Promoting Epithelial Basal Cell and Hair Follicle Stem Cell Proliferation

September 2017 in “ Experimental and Therapeutic Medicine ”

Shawn Tsai, Li‐Pen Tsao, Shih‐Hsin Chang, Tsung‐Chuan Ho, Kwang‐Yi Tung, Ai‐Ching Wu, Yeou‐Ping Tsao

pigment epithelium-derived factor PEDF epithelial basal cells hair follicle stem cells collagen deposition epithelialization

TLDR Shortened PEDF peptides speed up skin wound healing by boosting cell growth.

The study investigated the effects of pigment epithelium-derived factor (PEDF) short peptides on full-thickness skin wound healing in mice. The 20- and 29-amino-acid peptides significantly accelerated wound healing by promoting the proliferation of epithelial basal cells and hair follicle stem cells, enhancing re-epithelialization and granulation tissue formation. This led to faster wound closure and reduced scar formation. The findings suggested that these PEDF-derived peptides could be potential therapeutic agents for improving skin wound healing and tissue regeneration.

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Research cited in this study

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research Exploring the Role of Stem Cells in Cutaneous Wound Healing

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Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.

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Pigment Epithelium-Derived Factor Short Peptides Facilitate Full-Thickness Cutaneous Wound Healing by Promoting Epithelial Basal Cell and Hair Follicle Stem Cell Proliferation

Research cited in this study

research Exploring the Role of Stem Cells in Cutaneous Wound Healing

research Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells Into Corneal Epithelial-Like Cells

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

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research Overexpression Of Sonic Hedgehog Suppresses Embryonic Hair Follicle Morphogenesis