Pigment Epithelium-Derived Factor Short Peptides Facilitate Full-Thickness Cutaneous Wound Healing by Promoting Epithelial Basal Cell and Hair Follicle Stem Cell Proliferation

    September 2017 in “ Experimental and Therapeutic Medicine ”
    Shawn Tsai, Li‐Pen Tsao, Shih‐Hsin Chang … Yeou‐Ping Tsao
    Studysummary This study found that two short peptides derived from pigment epithelium-derived factor significantly accelerated full-thickness skin wound healing in mice through mechanisms that may involve increased cell proliferation and stem cell mobilization.
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    Research cited in this study 3

    1. Exploring the Role of Stem Cells in Cutaneous Wound Healing Experimental Dermatology · 2009
    2. Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells Into Corneal Epithelial-Like Cells Stem Cells · 2008
    3. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005

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