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Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Skin fat plays a key role in immune defense and healing beyond just storing energy.

Type I interferons play a key role in the development of various skin diseases.

Teriflunomide effectively reduces relapses and disability in MS and has a manageable safety profile.

Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.

Hormonal imbalances may play a role in frontal fibrosing alopecia, and antiandrogenic drugs combined with steroids are currently the most effective treatment.

Soy supplements improve various skin conditions and aging signs, with topical use boosting skin barrier function.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

New treatments and strategies are needed for Alopecia Areata, focusing on immune response and better trial designs.

New treatments and diagnostic methods for various animal skin conditions showed promising results.

Stabilizing HIF-1A in hair follicles may reduce oxidative stress and promote hair growth by increasing glycolysis.

The document concludes that various topical treatments show promise for skin conditions like atopic dermatitis, psoriasis, and hair loss.

Skin and hair renewal is maintained by both fast and slow cycling stem cells, with hair regrowth primarily driven by specific stem cells in the hair follicle bulge. These cells can also help heal wounds and potentially treat hair loss.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

Dandruff is mainly caused by a scalp reaction to yeast, can worsen hair loss, and antifungal treatments may help.

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Tcf3 helps cells move and heal wounds by controlling lipocalin 2.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Different lab conditions and light treatment methods change how human skin cells respond to light therapy.

SCF and ET-1 together significantly increase skin pigmentation and melanin production.

Microneedle made of iron oxide and PVA helps hair regrowth in alopecia treatment.

New physical methods like electrical currents, ultrasound, and microneedles show promise for improving drug delivery through the skin.

Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.

Different oil products cause varying levels of skin irritation in mice, which could potentially lead to tumors.

Scientists created keratinocyte cell lines from human hair that can differentiate similarly to normal skin cells, offering a new way to study skin biology and diseases.