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This source provides an overview of diagnostic and treatment innovations for gastrointestinal disorders, such as wireless capsule technology for motility assessment and new methods for treating constipation and nausea, highlighting both current and emerging techniques.

This study reported that a biotin-rich nutrition bar stored in aluminum foil packaging showed reduced bacterial growth and remained edible for 30 days compared to other packaging materials.

In this study, researchers developed a dissolvable microneedle patch containing baricitinib for alopecia areata treatment, reporting significantly higher hair growth in mouse models compared to controls, suggesting its potential as an effective, pain-free topical therapy.

This study found that finite element analysis-guided design improved bubble microneedles' controlled tip separation and insertion strength, supporting effective transdermal and sublingual drug delivery.

In this study on mice, a baricitinib-loaded microneedle patch enhanced hair growth in alopecia areata lesions (68% vs control: 33%, p < 0.05), suggesting it may deliver treatment effectively and pain-free, with fewer systemic side effects.

In this experimental study, researchers developed and optimized metformin-loaded mucoadhesive microspheres for sustained anti-hyperglycemic and anticancer activity, demonstrating high entrapment efficiency, enhanced α-amylase and α-glucosidase inhibition, improved cytotoxicity against breast cancer cells, and promising stability.

This study introduces a co-design framework using finite element analysis to optimize separable bubble microneedles, demonstrating enhanced transdermal and sublingual drug delivery in preclinical models. In vivo results showed faster hair regrowth and glucose lowering in animals, indicating potential improvements over traditional methods.

This study developed a co-design framework using finite element analysis to optimize bubble microneedles, achieving controlled tip separation and effective drug delivery through the skin and mucosa while maintaining insertion strength.

This study developed lipid-core nanocapsules for encapsulating menthol, improving its solubility and thermal stability, and demonstrated their safety and rapid skin absorption in ex vivo tests, highlighting potential applications for cosmeceuticals.

Created microspheres show potential for safe and effective use in prostate artery embolization.

This study found that bioactive glass-based camouflage composite particles enhanced the coagulation effects in bleeding models by forming a fibrin network and activating coagulation pathways, suggesting potential use as an emergency hemostasis biomaterial.

This study found that a nano-cubosome formulation co-loaded with capsaicin and thiocolchicoside enhanced bioavailability and showed promising analgesic and anti-inflammatory effects in rats, potentially benefiting gout management through improved transdermal delivery.

This study found that poly(propylene carbonate maleate) microspheres can successfully prolong finasteride release over 42 days, showing potential for long-term sustained drug delivery.

This chapter discusses the synthesis and analysis of near-infrared fluorescent activity-based probes for imaging cysteine protease activity, reporting potential benefits for disease diagnosis but noting challenges in imaging specific locations with high cathepsin activity.

This study found that novel biodegradable nanocarriers with highly hydrophobic cores significantly increased the solubility and sustained release of hydrophobic drugs and dyes, showing promise for drug delivery applications.

This review discusses alginate-based delivery systems for probiotics, highlighting recent advances, challenges, and future directions, but reports no new clinical findings.

This study reported the development of a workflow that combines SIMS and X-ray elemental mapping techniques for multimodal imaging at the single cell level, successfully applied to visualize elements, metals, and lipids in porcine skin without loss or delocalization.

This study demonstrated that the IVL-DrugFluidic® platform is effective for mass-producing finasteride-loaded polymeric microspheres for long-acting injectables, maintaining stable drug release without an initial burst for a month.

This review reports that cubosomes, used as drug nanocarriers in topical treatments, offer potential benefits for managing skin and eye diseases by improving bioadhesion, retention, and sustained release compared to conventional formulations, but also face manufacturing and biological challenges for effective clinical outcomes.

CUR-loaded micelles improve skin delivery and effects of curcumin for pain and infections.

This study explored the creation of 3D-printed baricitinib pills using polylactic acid and found that the doughnut-shaped tablets increased surface area and drug release, with 59% released from the higher concentration pill over 24 hours.

This study found that biodegradable hyperbranched polyesters improved the solubility and loading capacity of hydrophobic drugs, with complete pyrene release achieved in 16 days under enzymatic conditions.

This review discusses liposome-composite hydrogel microspheres as drug delivery systems, detailing their fabrication techniques, properties, and applications, but it reports no new experimental results.

This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.

This study found that capped mesoporous silica nanoparticles conjugated with antibodies selectively released a dye when exposed to finasteride, with low detection limits and stable performance even after storage.

This review discusses the potential of baghdadite ceramic for biomedical applications such as coatings and scaffolds, and reports no new experimental findings, emphasizing its promising properties and need for further research.

This study demonstrated that a microarray patch can deliver antibodies in a controlled and prolonged manner, maintaining their functionality after manufacturing and heat exposure, with successful pharmacokinetic proof-of-concept in rats.

The demineralized bone matrix scaffold is better for cell attachment than the mineralized bone allograft.

This study analyzed dosimetric quantities in x-ray microbeam radiation therapy and found that the peak-to-valley dose ratio decreases with depth in the irradiated object.

In this study, researchers found that niosomes, bilosomes, and spanlastic formulations can enhance the oral anticoagulation efficiency of rivaroxaban in rats, with spanlastic ranked as the most effective in prolonging clotting, prothrombin, and tail bleeding times compared to unprocessed rivaroxaban.