Preparation and Properties of Finasteride Loaded Poly(Propylene Carbonate Maleate) Sustained Release Microspheres

January 2014 in “ Journal of Central South University(Science and Technology) ”

Peng Dongmin

finasteride poly(propylene carbonate maleate) sustained release microspheres oil-in-water emulsion solvent evaporation Higuchi matrix model Propecia

TLDR PPCM microspheres can effectively release finasteride over 42 days.

The study investigated the use of poly(propylene carbonate maleate) (PPCM) as a carrier for finasteride in sustained release microspheres. These microspheres, prepared using an oil-in-water emulsion solvent evaporation method, had a mean diameter of approximately 2 μm. It was found that increasing the proportion of finasteride increased drug loading but decreased encapsulation efficiency, with optimal values of 14.78% drug loading and 66.17% encapsulation efficiency at a polymer-to-drug mass ratio of 5:1. In vitro testing in a pH 7.4 phosphate-buffered solution showed that the microspheres could prolong drug release up to 42 days, achieving a cumulative release of 92.59%. The drug release followed the Higuchi matrix model, indicating that PPCM was suitable for long-term sustained release drug delivery systems.

View this study on en.cnki.com.cn →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community 2 year progress on fin and minox

in Progress Pictures 1149 upvotes 5 years ago

A user's 2-year experience with Minoxidil and Finasteride as a treatment for hair loss, including the costs involved and potential side effects. Other users shared their experiences and asked questions about their own use of these treatments.

community Starting my journey taking fin 3 days a week. Minoxidil once daily. Pumpkin seed oil, biotin, zinc, and magnesium supplements daily. Strict no alcohol and no high sugar diet with regular exercise. Will post updates.

in Progress Pictures 17 upvotes 4 years ago

A user is starting a hair loss treatment regimen with finasteride three times a week, minoxidil once daily, and daily supplements of pumpkin seed oil, biotin, zinc, and magnesium. They are also following a strict no alcohol, no high sugar diet, and regular exercise, and plan to post updates.

community 5Months 0.5mg Fin + 2.5mg Oral Min | UPDATE #2

in Progress Pictures 920 upvotes 2 years ago

The user, Salty-Peace-577, shared their 5-month update on using 0.5mg oral finasteride and 2.5mg oral minoxidil for hair loss. They experienced significant hair growth, particularly in their eyebrows, and shared their regimen and tips for hair growth. Some users in the conversation also discussed the side effects they experienced with different dosages of the medications.

community Minox. 2.5 percent, Finasteride 1.25mg, Microneedling 1.5 mm, Ketoconazole shampoo and Biotin. Got better until it didn’t. Should I start dutasteride and Ru?

in What should I do? 90 upvotes 4 years ago

User experiencing hair loss tried Minoxidil, Finasteride, Microneedling, Ketoconazole shampoo, and Biotin. Others suggest continuing current treatment for 1-2 years before considering Dutasteride and RU58841.

community If anyone else feels like they’re too far gone for a hair transplant or can’t tolerate finasteride, I highly recommend trying a hair system! You have nothing to lose and it can change your life. I understand the worries and concerns, as I was very nervous/scared before taking the leap. AMA

in Hair Systems 394 upvotes 2 years ago

The conversation discusses the use of hair systems as a solution for hair loss. Users share their experiences, highlighting the natural look, confidence boost, and maintenance requirements of hair systems, while also addressing concerns about cost, stigma, and potential drawbacks.

community How a follicle next to it is so genetically different that it never miniaturized??

in Chat 219 upvotes 2 months ago

Genetic differences in hair follicles affect hair loss patterns. Treatments discussed include finasteride, dutasteride, minoxidil, and RU58841.

Similar Research

5 / 1000+ results

research Preparation of Novel Polymeric Microspheres for Controlled Release of Finasteride

37 citations , May 2007 in “International Journal of Pharmaceutics”

PPCM microspheres allow controlled finasteride release over 24 hours.

Pharmacokinetic-Pharmacodynamic Modeling Approach for Dose Prediction of the Optimal Long-Acting Injectable Formulation of Finasteride

research Pharmacokinetic-Pharmacodynamic Modeling Approach for Dose Prediction of the Optimal Long-Acting Injectable Formulation of Finasteride

6 citations , March 2021 in “International Journal of Pharmaceutics”

Optimal long-acting finasteride injection dose found: 16.8 mg, effective for one month.

research Development of Finasteride Polymer Microspheres for Systemic Application in Androgenic Alopecia

6 citations , March 2019 in “International Journal of Molecular Medicine”

Finasteride microspheres help reduce hair loss for up to eight weeks with fewer side effects.

research Biomaterials For Treatment Of Baldness

November 2022 in “Cureus”

New biomaterial treatments for baldness show promise, with options depending on patient needs.

research Nanomaterials in Hair Care and Treatment

5 citations , February 2022 in “Acta Biomaterialia”

Nanomaterials can improve hair care products and treatments, including hair loss and alopecia, by enhancing stability and safety, and allowing controlled release of compounds, but their safety in cosmetics needs more understanding.