Preparation, Optimization, In Vitro Evaluation and Ex Vivo Permeation Studies of Finasteride Loaded Gel Formulations Prepared Using Response Surface Methodology

    September 2018 in “ Current Drug Delivery ”
    Muhammad Shahzeb Khan, Petre Makreski, Ghulam Murtaza
    TLDR The combination of propylene glycol and Tween® 80 improves finasteride gel effectiveness.
    The study aimed to prepare and optimize finasteride-loaded topical gel formulations using a central composite design with three factors: propylene glycol (PG), Tween® 80, and sodium lauryl sulphate (SLS). The optimized formulation (F4) containing 0.8 mg PG, 0.4 mg Tween® 80, and 0.2 mg SLS showed significantly higher values of cumulative drug release, flux, partition coefficient, input rate, lag time, and diffusion coefficient compared to the control. The study concluded that while each enhancer individually improved finasteride permeation, the combination of PG and Tween® 80 had a synergistic effect on flux, permeability coefficient, and input rate, but an antagonistic effect on lag time and diffusion coefficient.
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