FEA-Guided Co-Design of Bubble Microneedles: Controlled Tip Separation for Rapid Transdermal and Sublingual Delivery

    May 2026 in “ Drug Delivery ”
    Changzhao Jiang, Jie Yang, Mengxuan Gao … Jincui Ye
    Studysummary This study introduces a co-design framework using finite element analysis to optimize separable bubble microneedles, demonstrating enhanced transdermal and sublingual drug delivery in preclinical models. In vivo results showed faster hair regrowth and glucose lowering in animals, indicating potential improvements over traditional methods.
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    Research cited in this study 3

    1. Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment Acta Pharmaceutica Sinica B · 2024
    2. Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging Nature Aging · 2023
    3. Dissolving Microneedle Patch Integrated With Microspheres For Long-Acting Hair Regrowth Therapy ACS Applied Materials & Interfaces · 2023