Core-Shell Nanocarriers Based on PEGylated Hydrophobic Hyperbranched Polyesters

The document from 2016 details the creation and evaluation of PEGylated hydrophobic hyperbranched polyester (HBPES) core-shell nanocarriers for drug delivery systems. Two types of nanocarriers with different hydrophobicities were synthesized, showing an average molecular weight of approximately 6 KDa and an average of 27% functionalization with PEG. The nanocarriers demonstrated the ability to enhance the solubility of hydrophobic drugs, with a maximum loading capacity of 12.1 wt% for Finasteride and 6.9 wt% for Dexamethasone. Pyrene was used as a model compound to test drug release, achieving complete release within 16 days under enzymatic conditions. The study concluded that the hydrophobicity of the core significantly increases the loading capacity for hydrophobic drugs and that these nanocarriers offer controlled release, indicating their potential as efficient drug delivery systems.