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The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

Follicular mycosis fungoides can look like a B-cell lymphoma, making diagnosis difficult.

Skin lymphoproliferative disorders are hard to diagnose and often linked to systemic diseases, but most have a good prognosis with accurate diagnosis.

A new TP63 mutation was found in a baby with EEC syndrome, showing the need for TREC testing to check for immune issues.

Melatonin affects certain genes and pathways involved in cashmere goat hair growth.

Cats likely have a reactive skin condition, while dogs may have a more complex, possibly cancerous one.

A boy with severe immune deficiency and Epstein-Barr virus died from high-grade B-cell lymphoma.

CD8+ T cells are involved in alopecia areata and may cause disease relapse.

FoxN1 overexpression in young mice harms immune cell and skin development.

Hair loss may link to weaker COVID-19 immunity, suggesting possible need for extra vaccine boost.

FOXN1 gene variants cause low T cells and immune issues from birth.

XEDAR triggers a specific signaling pathway in cells.

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Men are more likely to have severe respiratory viral infections like COVID-19 due to hormonal and genetic differences, while women generally have stronger immune responses.

Bendamustine, often combined with other drugs, is effective and less toxic for certain blood cancers, but less effective for young, fit patients with CLL.

TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.

Newborn screening and gene therapy are expected to improve outcomes for Omenn syndrome patients.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Scientists are still unsure what triggers the immune system to attack hair follicles in Alopecia areata.

A 10-month-old boy with a rare combination of genetic conditions has severe immune deficiency and treatment challenges.

A mutation in the IKZF1 gene causes immune system overactivity, linked to autoimmune diseases like lupus.

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

New treatments targeting T-cell pathways are needed for better alopecia areata management.

T cells and bacteria in the gut and skin help maintain health and protect against disease.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.