Epstein-Barr Virus Associated with High-Grade B-Cell Lymphoma in Severe Combined Immunodeficiency

    May 2019 in “ BMJ case reports ”
    Rawia Albar, Moaffaq Mahdi, Fawaz Alkeraithe, Khalid Nawaf Almufarriji
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    TLDR A boy with severe immune deficiency and Epstein-Barr virus died from high-grade B-cell lymphoma.
    A 4-month-old boy with severe combined immunodeficiency (SCID) caused by a homozygous variant in the FOXN1 gene presented with fever, dry cough, runny nose, oral thrush, generalized lymphadenopathy, nail dystrophy, and alopecia. Flow cytometry of a lymph node biopsy revealed high-grade B-cell lymphoma, and PCR confirmed Epstein-Barr virus (EBV) infection. Despite initiating treatment for EBV infection and lymphoma, the patient passed away on day 45 of hospitalization.
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