Epstein-Barr Virus Associated with High-Grade B-Cell Lymphoma in Severe Combined Immunodeficiency

    May 2019 in “ BMJ case reports ”
    Rawia Albar, Moaffaq Mahdi, Fawaz Alkeraithe, Khalid Nawaf Almufarriji
    Studysummary This report describes a rare case of severe combined immunodeficiency caused by a FOXN1 gene variant, complicated by Epstein-Barr virus infection and high-grade B-cell lymphoma, leading to the infant's death despite treatment efforts.
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    Research cited in this study 5

    1. FOXN1 Deficiency: From the Discovery to Novel Therapeutic Approaches Journal of clinical immunology · 2017
    2. FOXN1 Italian Founder Mutation in Indian Family: Implications in Prenatal Diagnosis Gene · 2017
    3. FOXN1 Deficient Nude Severe Combined Immunodeficiency Orphanet journal of rare diseases · 2017
    4. Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation PloS one · 2012
    5. First Use of Thymus Transplantation Therapy for FOXN1 Deficiency (Nude/SCID): A Report of 2 Cases Blood · 2011