80 citations
,
January 1995 in “The Nephron journals/Nephron journals” This study concluded that a sequential regimen of prednisolone and cyclophosphamide, followed by low-dose prednisolone and azathioprine, achieved favorable results in most patients with diffuse proliferative and/or membranous lupus nephritis without significant toxicities.
54 citations
,
May 2019 in “Multiple Sclerosis and Related Disorders” This study found that azathioprine may improve relapses and disability in patients with neuromyelitis optica spectrum disorder but is associated with higher adverse events compared to mycophenolate mofetil.
42 citations
,
January 1998 in “BioDrugs” Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.
34 citations
,
February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.
21 citations
,
August 1984 in “BJOG An International Journal of Obstetrics & Gynaecology” This study found no differences in ovarian function between renal transplant recipients treated with either cyclosporin A or azathioprine and prednisone, although excessive hair growth was common in both groups.
16 citations
,
January 2013 in “Pediatric Gastroenterology Hepatology & Nutrition” This study found that azathioprine treatment in Korean children with inflammatory bowel disease frequently led to adverse events, with bone marrow suppression being the most common.
12 citations
,
August 2020 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study found that most chronic alopecia areata patients treated with azathioprine, methotrexate, or cyclosporine continued treatment for at least 12 months, often requiring concurrent low-dose prednisolone.
10 citations
,
August 2020 in “Drug metabolism and drug interactions” This case series found that patients with the NUDT15 415C>T variant experienced severe azathioprine toxicity, suggesting genotype-based dosing could reduce adverse effects.
10 citations
,
July 2019 in “Indian Journal of Dermatology” This study found that azathioprine pulse therapy and betamethasone both effectively managed alopecia areata with similar hair regrowth results, though betamethasone had significantly more side effects, suggesting azathioprine as a preferable alternative to corticosteroids.
8 citations
,
April 2018 in “Journal of the European Academy of Dermatology and Venereology” This letter discusses azathioprine-induced alopecia and leukopenia potentially linked to NUDT15 polymorphisms, reporting no new clinical results.
8 citations
,
January 2018 in “Middle East Journal of Digestive Diseases” This case report describes a middle-aged man with alopecia universalis and ulcerative colitis, where hair regrowth occurred following treatment with azathioprine and mesalamine.
7 citations
,
May 2010 in “Journal of Dermatological Treatment” This case report describes a patient with various conditions, including ulcerative colitis and azathioprine-induced liver injury, and reviews related literature on these coexisting conditions.
7 citations
,
July 1990 in “Journal of the American Academy of Dermatology” This case report describes a patient who developed severe alopecia and a rash after increasing captopril dosage, which resolved upon discontinuing the medication.
6 citations
,
April 2018 in “Transplantation proceedings” This case report describes severe agranulocytosis and alopecia in a Japanese woman after starting azathioprine, highlighting the potential role of NUDT15 genetic screening in preventing adverse reactions to the drug.
5 citations
,
February 1997 in “Bioorganic & Medicinal Chemistry” This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.
3 citations
,
August 2021 in “Clinical Case Reports” This case report describes a patient with a NUDT15 minor variant who experienced severe myelosuppression due to azathioprine, emphasizing typical symptoms as clues to the adverse reaction.
3 citations
,
May 2007 in “Journal of Heterocyclic Chemistry” This study reports a new industrial process for making finasteride using novel protective groups, demonstrated through spectral data of newly prepared compounds.
3 citations
,
September 2021 in “Journal of Nepal Medical Association” This case report describes successful treatment of alopecia universalis associated with severe hyperthyroidism using azathioprine and hydroxychloroquine after poor response to oral steroid therapy.
2 citations
,
March 2015 in “Clinical and Experimental Dermatology” This article addresses an unusual side effect of azathioprine but provides no abstract or detailed results, focusing instead on a specific dermatological perspective.
1 citations
,
May 2023 in “Frontiers in Pharmacology” In this study, a case of a young Chinese female with a specific NUDT15 genetic variant experienced severe azathioprine-induced myelosuppression and alopecia while treating systemic lupus erythematosus, highlighting the need for routine blood monitoring during treatment to manage AZA intolerance associated with genetic factors.
1 citations
,
January 2024 in “Dermatologic Therapy” This study found that both methotrexate and azathioprine were equally effective and well-tolerated in improving symptoms of lichen planopilaris over six months, with no significant difference between the two treatments in terms of efficacy.
1 citations
,
January 2023 in “Research Square (Research Square)” This study found that a neem-based herbal formulation may be more effective than ivermectin in treating sarcoptic mange in dromedary camels, leading to complete recovery without scarring or keratinization.
1 citations
,
April 2019 in “Acta Medica Philippina” This review discusses emerging evidence on azathioprine's efficacy and safety for severe alopecia areata, reporting sustained response in many patients but emphasizing the need for controlled trials.
1 citations
,
January 2016 in “International journal of research in ayurveda and pharmacy” This study found that a herbal formulation optimized with specific concentrations of plant extracts showed promising antifungal activity against Malassezia furfur.
1 citations
,
January 2007 in “Heterocyclic Communications” This study reports a new method for selectively synthesizing finasteride Form-I in good yield using water as an ecofriendly solvent at room temperature.
This case report details a 45-year-old woman with SLE who experienced severe leukopenia and hair loss attributed to azathioprine, suggesting the importance of recognizing these potential adverse effects for timely intervention.
January 2024 in “Journal of Clinical Rheumatology and Immunology” In this case report, researchers described a severe case of myelosuppression and alopecia totalis in a patient with systemic lupus erythematosus following azathioprine treatment, highlighting the importance of monitoring for these uncommon side effects.
October 2012 in “Organic Process Research & Development” This study developed a new crystallization method using solid solution formation to purify finasteride by effectively removing contamination with dihydrofinasteride.
April 2025 in “Journal of Cosmetic Dermatology” In this study, researchers found that azathioprine significantly improved hair regrowth in patients with moderate to severe alopecia areata over 10 years, with hair loss decreasing from 74.2% to 5.2% and demonstrating long-term safety and efficacy.
April 2017 in “Childhood Kidney Diseases” This case report describes severe myelosuppression and alopecia totalis in a 10-year-old boy after azathioprine treatment for IgA nephropathy, which resolved after stopping the drug and receiving granulocyte colony-stimulating factor.