Novel Azaandrostane Derivatives for the Synthesis of 17β-(N-tert-butyl Carbamoyl)-4-aza-5α-androst-1-ene-3-one

May 2007 in “ Journal of Heterocyclic Chemistry ”

Divvela V. N. Srinivasa Rao, Ganala Naga Trinadhachari, K. Joseph Prabahar, Ramesh Dandala, Meenakshisundaram Sivakumaran, Andra Naidu

finasteride azaandrostane derivatives 17β‐(N‐tert‐butyl carbamoyl)‐4‐aza‐5α‐androst‐1‐ene‐3‐one benzoyl group lactamic NH group Propecia

TLDR A new method to make finasteride for hair loss treatment was developed.

The document reported a new industrially viable process for synthesizing finasteride, a compound used in hair loss treatment, from novel azaandrostane derivatives. The process utilized a benzoyl group as a novel protecting group for the lactamic NH group. The structures of the newly prepared compounds were confirmed using spectral data, including IR, 1H-NMR, and MS.

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