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research Novel azaandrostane derivatives for the synthesis of 17β‐(N‐tert‐butyl carbamoyl)‐4‐aza‐5α‐androst‐1‐ene‐3‐one

3 citations , May 2007 in “Journal of Heterocyclic Chemistry”

This study reports a new industrial process for making finasteride using novel protective groups, demonstrated through spectral data of newly prepared compounds.

research FACILE WATER MEDIATED SYNTHESIS OF FINASTERIDE FORM-I, AN AZAANDROSTANE STEROID

1 citations , January 2007 in “Heterocyclic Communications”

This study reports a new method for selectively synthesizing finasteride Form-I in good yield using water as an ecofriendly solvent at room temperature.

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research AN EFFICIENT SYNTHESIS OF DUTASTERIDE: UTILIZING BENZOYL GROUP AS NOVEL LACTAMIC PROTECTING GROUP

January 2017 in “Rasayan journal of Chemistry”

This paper describes a new scalable synthesis method for Dutasteride, highlighting its potential for large-scale commercial production.

research A Review of U.S. Patents in the Field of Organic Process Development Published during July and August 2004

2 citations , October 2004 in “Organic Process Research & Development”

This review discusses U.S. patents in organic process development published in July and August 2004 and reports no new experimental results.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

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Community Join

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community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Intriguing Molecular Structures and Questions (DHT, Progesterone, Fin, etc)

7 upvotes 2 years ago

The conversation discusses the molecular structures of compounds that reduce DHT levels, including finasteride and Ashwagandha. It explores the potential of using Ashwagandha topically as a 5a reductase inhibitor.

community Androgen degraders for hair loss

61 upvotes 2 years ago

The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

community What are some topical anti androgens(not dht).

3 upvotes 3 months ago

The conversation is about exploring topical anti-androgens for hair loss, specifically mentioning Bicalutamide and the unpleasant smell of Spironolactone. RU58841 is unavailable, and Breezula is suggested as an alternative.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

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